Transgenic mice which express simian SV 40 T-antigen under contr

Details Transgenic mice which express simian SV 40 T-antigen under contr Transgenic mice which express simian SV 40 T-antigen under contr

1995-05-08

1998-03-17

Stanton, Brian R.

Multicellular living organisms and unmodified parts thereof and

Nonhuman animal

4351723, 435354, 536 241, C07H 2104, C12N 518, C12N 1500

Patent

active

057289158

ABSTRACT:
Transgenic mice whose germ cells and somatic cells contain a simian SV40 T-oncogene operably linked to the promoter of the retinoblastoma susceptibility (RB) gene effective for expression of the T-oncogene in somatic cells of the mouse under control of the promoter spontaneously develop tumors of the ocular tissues as well as osteosarcomas and soft-tissue sarcomas. Such transgenic mice are useful as sources of tissue cultures of tumor cells and as animal models for the occurrence of osteosarcomas and soft-tissue sarcomas in humans and other animals.

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Zhu et al., 1995 "Regulational and Functional Analysis of the Human retinoblastoma susceptibility gene during development and tumorigenesis", Dissabs Accession No. 95:55830.

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