Transgenic mice overexpressing aspartyl protease 2 (ASP2)

Details Transgenic mice overexpressing aspartyl protease 2 (ASP2) Transgenic mice overexpressing aspartyl protease 2 (ASP2)

2005-10-25

2005-10-25

McKelvey, Terry (Department: 1636)

Multicellular living organisms and unmodified parts thereof and

Nonhuman animal

Transgenic nonhuman animal

C800S012000, C536S023100, C536S023500, C536S024100, C435S354000

Reexamination Certificate

active

06958433

ABSTRACT:
The present invention provides a recombinant DNA construct comprising a coding sequence encoding human ASP2 and a brain-specific calcium calmodulin kinase promoter sequence which is operably linked to the coding sequence. The present invention further provides a transgenic non-human animal whose genome incorporates a polynucleotide comprising a coding sequence which encodes the human ASP2 protein wherein the coding sequence is operably linked to a brain-specific calcium calmodulin kinase II promoter.

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