Multicellular living organisms and unmodified parts thereof and – Nonhuman animal – The nonhuman animal is a model for human disease
Reexamination Certificate
2005-05-10
2005-05-10
Crouch, Deborah (Department: 1632)
Multicellular living organisms and unmodified parts thereof and
Nonhuman animal
The nonhuman animal is a model for human disease
C800S003000, C800S008000, C800S009000, C800S013000, C800S018000, C435S455000, C435S463000, C435S320100, C435S325000
Reexamination Certificate
active
06891081
ABSTRACT:
The present invention provides for a transgenic non-human animal whose cells contain a recombinant DNA sequence comprising a nerve tissue specific promoter operatively linked to a DNA sequence which encodes amyloid-beta peptide alcohol dehydrogenase (ABAD), and exhibits at least one phenotype from the group consisting of: overexpression of ABAD, elevated levels of basal ATP; protection from metabolic or ischemic stress.
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Stern David M.
Yan Shi Du
Cooper & Dunham LLP
Crouch Deborah
The Trustees of Columbia University in the City of New York
Ton Thai-an N.
White John P.
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