Transgenic mice having modified cell-cycle regulation

Details Transgenic mice having modified cell-cycle regulation Transgenic mice having modified cell-cycle regulation

1996-04-04

1999-07-06

Crouch, Deborah

Multicellular living organisms and unmodified parts thereof and

Nonhuman animal

Transgenic nonhuman animal

800 25, 800 22, 800 3, 435455, 435463, 435467, 435325, 4353201, 435 912, 424 921, C12N 1500, C12N 1509, C12N 1563, C12N 500

Patent

active

059199970

ABSTRACT:
The present invention relates to transgenic mice in which the biological function of at least one cell cycle regulatory proteins of the INK4 family is altered.

REFERENCES:
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Kappel et al., Current Opinion in Biotechnology, vol. 3, pp. 548-553, 1992.
Bradley et al., Biotechnology, vol. 10, pp. 534-539, May 1992.
Stojek & Wagner, Genetic Engineering, vol. 10, pp. 221-246, 1988.
Mansour et al., Nature, vol. 336, pp. 349-352, Nov. 24, 1988.
Serrano et al., Nature, vol. 366, pp. 704-707, Dec. 16, 1993.

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