Transgenic mice expressing TSSV40 large T antigen

Details Transgenic mice expressing TSSV40 large T antigen Transgenic mice expressing TSSV40 large T antigen

1997-07-02

1999-02-02

Crouch, Deborah

Multicellular living organisms and unmodified parts thereof and

Nonhuman animal

435354, 935 59, C12N 500, C12N 1500

Patent

active

058667598

ABSTRACT:
The provision of cell lines from virtually any cell type of the animal body is greatly facilitated by transgenic non-human eukaryotic animals of the invention in which at least some cells have (i) a differentiation inhibiting sequence chromosomally incorporated under the control of a non-constitutive promotor and/or (ii) a differentiation inhibiting sequence which is itself conditionally active. Said genes are chromosomally incorporated under the control of a promotor such that expression of said sequence is normally held below an effective level, thus allowing normal cell development. However, cells taken from said animal may be prevented from completing differentiation to a non-dividing state in tissue culture by activating expression of said sequence.

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