Transgenic mice expressing the neurotoxic C-terminus of .beta.-a

Details Transgenic mice expressing the neurotoxic C-terminus of .beta.-a Transgenic mice expressing the neurotoxic C-terminus of .beta.-a

1991-07-18

1997-09-30

Crouch, Deborah

Multicellular living organisms and unmodified parts thereof and

Nonhuman animal

800DIG1, 424 92, 935 62, C12N 500, C12N 1500, A61K 4900

Patent

active

056728050

ABSTRACT:
The present invention provides non-human, transgenic animals for use as a model for the study of Alzheimer's Disease. The animals exhibit pathology associated with Alzheimer's Disease. The phenotype is conferred in the animals by the introduction of an amyloid-containing polypeptide fragment of amyloid precursor protein, through the introduction of the DNA into the germ and somatic cells of the animal by transgenic methods.

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