Multicellular living organisms and unmodified parts thereof and – Nonhuman animal – Transgenic nonhuman animal
Patent
1997-06-27
2000-08-29
LeGuyader, John L.
Multicellular living organisms and unmodified parts thereof and
Nonhuman animal
Transgenic nonhuman animal
800 9, 800 13, 800 24, 435 6, 435 696, 4353201, 435355, 435455, 435375, A61K 6702, C12Q 168, C12N 1585
Patent
active
06111166&
ABSTRACT:
Transgenic animals expressing Fc receptors and uses for the animals in testing the efficacy of human antibodies and in generating novel antibodies are described.
REFERENCES:
patent: 4954617 (1990-09-01), Fanger et al.
patent: 5610057 (1997-03-01), Shen et al.
patent: 5635600 (1997-06-01), Fanger et al.
van de Winkel. Journal of Biological Chemistry. 266 (20): 13449-13455, 1991.
de Wit. Journal of Immunology. 155: 1203-1209, 1995.
Heijnen et al. Journal of Clinical Investigation. 97(2): 331-338, Jan. 1996.
Greenspan et al. Journal of Immunology. 150(8-2):66A, 1993.
Ravetch et al. Annual Review of Immunology. 9: 457-92, 1991.
Fung-Leung et al. Journal of Experimental Medicine. 183: 49-56, Jan. 1996.
Kinet et al. Proceedings of the National Academy of Sciences. 85: 6453-6487, 1988.
Shimizu et al. Proceedings of the National Academy of Sciences. 85: 1907-1911, 1988.
Mullins et al. Journal of Clinical Investigation. 98(11): S37-40, 1996.
Strojek et al. Genetic Engineering: Principles and Methods. Plenum Press. 10: 221-246, 1988.
Ashworth, L. et al.,"An Integrated Metric Physical Map of Human Chromosome 19", Nature Genetics, vol. 11, pp. 422-427 (1995).
Anderson, C. et al.,"Stimulation of Superoxide Production by a Monoclonal Antibody (mab) Against the High Affinity IgG Fc Receptor (FcRI) of U937 Cells", Fed. Proc., vol. 45, Abstract #3247, pp. 714 (1986).
Ball, E. et al.,"Initial Trail of Bispecific Antibody-Mediated Immunotherapy of CD15 Bearing Tumors: Cytotoxicity of Human Tumor Cells Using a Bispecific Antibody Comprised of Anti-CD15 (MoAb PM81) and Anti-CD64/Fc.gamma.RI (MoAb 32)", J. of Hematotherapy, vol. 1, pp. 85-94 (1992).
Chen, J. et al., "An Immunoconjugate of Lys3-Bombesin and Monoclonal Antibody 22 Can Specifically Induce FcgammaRI (CD64)-Dependent Monocyte- and Neutrophil-Mediated Lysis of Small Cell Carcinoma of the Lung Cells" Clinical Cancer Research, vol. 1 (4), pp. 425-434 (1995).
Clark, M. et al., "Use of Bispecific Monoclonal Antibodies to Treat Hematological Malignancies: A Model System Using CD3 Transgenic Mice", Bispecific Antibodies and Targeted Cellular Cytotoxicity, Edited by Romet-Lemonne et al., Fondation Nationale de Transfustion Sanguine, Les Ulis, France, pp. 243-247 (1990).
Deo, Y. et al., "Clinical Significance of IgG Fc Receptors and Fc.gamma.-directed Immunotherapies", Immunology Today, vol. 18 (3), pp. 127-135 (1997).
de Palazzo, I. et al.,"Potentiation of Tumor Lysis by a Bispecific Antibody that Binds to CA19-9 Antigen and the Fc.gamma. Receptor Expressed by Human Large Granular Lymphocytes", Cancer Research, vol. 50, pp. 7123-7128 (1990).
de Wit, T. et al.,"Structure of the Gene for the Human Myeloid IgA Fc Receptor (CD89)", Journal of Immunology, vol. 155, pp. 1203-1209 (1995).
Ericson, S. et al., "The Effect of Recombinant Human Interleukin-3 and Recombinant Human Granulocyte-macro-Phage Colony-Stimulating Factor on Fc.gamma. Receptor Expression and Antibody-Dependent Cellular Cytotoxicity of Hematopoietic Progenitor Cells During in Vitro Myeloid Maturation", Experimental Hematology, vol. 22, pp. 283-289 (1994).
Fanger, M. et al., "Production and Use Of Anti-FcR Bispecific Antibodies" Immunomethods vol. 4 (1), pp. 72-81 (1994).
Fanger, M. et al., "Fc.gamma. Receptors in Cancer and Infectious Disease", Immunol. Res., vol. 11, pp. 203-216 (1992).
Fanger, M. et al., "Bispecific Antibodies" Critical Reviews in Immunology, vol. 12 (3,4), pp. 101-124 (1992).
Graziano, R. et al., "Construction and Characterization of a Humanized Anti-Gamma-Ig Receptor Type I (Fcgamma RI) Monoclonal Antibody" The Journal of Immunology, vol. 155 (10): 4996-5002 (1995).
Guyre, P. et al., "Monoclonal Antibodies that Bind to Distinct Epitopes on Fc.gamma.RI are able to Trigger Receptor Function" ,The Journal of Immunology, vol. 143 (5), pp. 1650-1655 (1989).
Guyre, P. et al., "Recombinant Immune Interferon Increases Immunoglobulin G Fc Receptors on Cultured Human Mononuclear Phagocytes", Journal of Clinical Investigation, vol. 72, pp. 393-397 (1983).
Isturiz, M. et al., "Two Different Fc.gamma. Receptor-Dependent Cytotoxic Mechanisms Triggered by Monoclonal Immunoglobulins", Immunology Letters, vol. 29, pp. 271-276 (1991).
Jung, Gundram, et al., "Target Cell-Induced T cell Activation with Bi- and Trispecific Antibody Fragments", Eur. J. Immunol., vol. 21, pp. 2431-2435 (1991).
Keler, T. et al., "Bispecific Antibody (MDX-210) Targeting of Tumor Cells to Monocytes Via the Fc Receptor Type I (Fc.gamma.RI) Promotes Antibody Dependent Cellular Cytotoxicity (ADCC) and Induction of Specific Cytokines," Proceedings of the American Association for Cancer Research, vol. 36, 485 (1995).
Keler, T. et al.,"Bispecific Antibody-dependent Cellular Cytotoxicity of HER2
eu-overexpressing Tumor Cells by Fc.gamma. Receptor Type I-expressing Effector Cells", Cancer Research, vol. 57, pp. 4008-4014 (1997).
Kubagawa, H. et al., "Cloning of Genes Encoding Possible Murine Fc.alpha. Receptors (Fc.alpha.R)," FASEB J., vol. 8, No. 4-5, A749 (1994).
Looney, R. et al., "Human Monocytes and U937 Cells Bear Two Distinct Fc Receptors for IgG", The Journal of Immunology, vol. 136 (5), pp. 1641-1647 (1986).
Lubeck, M. et al., "The Interaction of Murine IgG Subclass Proteins with Human Monocyte Fc Receptors", The Journal of Immunology, vol. 135 (2), pp. 1299-1304 (1985).
Mabondzo, A. et al., "Antibody-dependent Cellular Cytotoxicity and Neutralization of Human Immunodeficiency Virus Type 1 by High Affinity Corss-Linking of gp41 to Human Macrophage Fc IgG Receptor Using Bispecific Antibody", Journal of Virology, vol. 75, pp. 1451-1456 (1994).
Monteiro, R. et al., "Definition of Immunoglobulin A Receptors on Eosinophils and their Enhanced Expression in Allergic Individuals," J. Clin Invest., vol. 92, 1681-1685 (1993).
Monteiro, R. et al., "Molecular Heterogeneity of Fc.alpha. Receptors Detected by Receptor-Specific Monoclonal Antibodies," The Journal of Immunology, vol. 148, No. 6, 1764-1770 (1992).
Morton, C. et al.,"Structure and Function of Human IgA Fc Receptors (Fc.alpha.R)", Critical Reviews in Immunology, vol. 16, pp. 423-440 (1996).
Patry, C. et al., "Fc.alpha. Receptors Mediate Release of Tumour Necrosis Factor-.alpha. and Interleukin-6 by Human Monocytes Following Receptor Aggregation," Immunology, vol. 86, 1-5 (1995).
Patry, C. et al.,"Identification of Fc.alpha. Receptor (CD89) Isoforms Generated by Alternative Splicing that are Differentially Expressed Between Blood Monocytes and Alveolar Macrophages", Journal of Immunology, vol. 156, pp. 4442-4448 (1996).
Pfefferkorn, L. and Yeaman, G., "Association of IgA-Fc Receptors (Fc.alpha.R) with Fc.epsilon.RI.gamma.2 Subunits in U937 Cells," The Journal of immunology, vol. 153, 3228-3236 (1994).
Repp, R. et al., "G-CSF Stimulated Neutrophils As Effector Cells In Immunotherapy With A Bispecific Antibody to FcgammaRI and To HER-2
eu (MDX210): Preclinical Studies", Immunobiology, vol. 191 (2-3): 250-251 (1994).
Sarmay, G. et al., "Mapping and Comparison of the Interaction Sites on the Fc region of IgG Responsible for Triggering Antibody Dependent Cellular Cytotoxicity (ADCC) Through Different Types of Human Fc.gamma. Receptor", Molecular Immunology, vol. 29 (5), pp. 633-639 (1992).
Shen, L. et al., "Direct Stimulation of ADCC by cloned Gamma Interferon is not Ablated by Glucocorticoids: Studies Using a Human Monocyte-like Cell Line (U-937)", Molecular Immunology, vol. 21 (2), pp. 167-173 (1984).
Shen, L. et al., "Heteroantibody-Mediated Cytotoxicity: Antibody to the High Affinity Fc Receptor for IgG Mediates Cytotoxicity by Human Monocytes that is Enhanced by Interferon-.gamma. and is not Blocked by Human IgG", The Journal of Immunology, vol. 137 (11), pp. 3378-3382 (1986).
Shen, L., "Receptors for IgA on Phagocytic Cells," Immunol. Res., vol. 11, 273-282 (1992).
Shen, L. et al., "My 43, A Monoclonal Antibody That Reacts with Human Myeloid Cells Inhibits Monocyte IgA Binding and Triggers Function," Journal of Immunology, vol. 143, No. 12, 4117-4122 (1989).
Shimada, T. et al., "Comparative Analysis of Fc.alpha.R on Neutrophils and Monocytes," FASEB J.
DeConti, Jr. Esq. Giulio A.
LeGuyader John L.
Medarex, Incorporated
Remillard, Esq. Jane E.
Stroup Carrie
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