Transgenic mice expressing APC resistant factor V

Details Transgenic mice expressing APC resistant factor V Transgenic mice expressing APC resistant factor V

1996-11-06

2000-05-23

Chambers, Jasemine C.

Multicellular living organisms and unmodified parts thereof and

Nonhuman animal

800DIG1, 800DIG4, 424 92, 4351723, C12N 500, A61K 4900

Patent

active

060667788

ABSTRACT:
The present invention relates to compositions and methods for the screening of compounds for anticoagulant activity. In particular, the present invention relates to non-human transgenic animals expressing activated protein C ("APC")-resistant factor V proteins which display a predisposition toward spontaneous thrombosis. The present invention also provides methods for using these transgenic animals to screen compounds for anticoagulant activity.

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Dahlback and Hildebra

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