Transgenic mice depleted in mature T-cells and methods for makin

Details Transgenic mice depleted in mature T-cells and methods for makin Transgenic mice depleted in mature T-cells and methods for makin

1992-07-27

1995-07-18

Chambers, Jasemine C.

Multicellular living organisms and unmodified parts thereof and

Nonhuman animal

800DIG1, 4351723, 935111, C12N 1500

Patent

active

054343402

ABSTRACT:
Transgenic mice having a phenotype characterized by the substantial absence of mature T lymphocytes otherwise naturally occurring in said mice. The phenotype is conferred in the transgenic mouse by a transgene contained in at least the precursor stem cell of the T lymphocyte which is depleted. The transgene comprises a DNA sequence encoding a T cell receptor polypeptide variant which inhibits maturation of the T lymphocyte.

REFERENCES:
patent: 5175384 (1992-12-01), Krimpenfort et al.
Van Brunt, Bio Technology 6(10):1149-1154 (1988).
Wilmut et al., New Scientist, Jul. 7, 1988, pp. 56-59.

Affiliated with

Also associated with

Rating

Transgenic mice depleted in mature T-cells and methods for makin does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Transgenic mice depleted in mature T-cells and methods for makin, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Transgenic mice depleted in mature T-cells and methods for makin will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-2419598