Transgenic mice depleted in mature T-cells and methods for makin

Details Transgenic mice depleted in mature T-cells and methods for makin Transgenic mice depleted in mature T-cells and methods for makin

1988-12-05

1992-12-29

Weimar, Elizabeth C.

Multicellular living organisms and unmodified parts thereof and

Nonhuman animal

800DIG1, 4351723, 935111, C12N 1500

Patent

active

051753847

ABSTRACT:
Transgenic mice having a phenotype characterized by the substantial absence of mature T lymphocytes otherwise naturally occurring in said mice. The phenotype is conferred in the transgenic mouse by a transgene contained in at least the precursor stem cell of the T lymphocyte which is depleted. The transgene comprises a DNA sequence encoding a T cell receptor polypeptide variant which inhibits maturation of the T lymphocyte.

REFERENCES:
Wilmut et al., New Scientist, Jul. 7, 1988, pp. 56-59.
Van Brunt, Biotechnology, 6(10): 1149, 1151, 1152, 1154 (1988).
Bluthmann et al., Nature, 334:156-159 (1988).
Kisielow et al., Nature 333:742-746 (1988).
Uematsu et al., Cell 52:831-841 (1988).
Fenton et al., Science 241:1089-1092 (1988).
Nussenzweig et al., Science 236:816-819 (1987).
Boehmer et al., Proc. Natl. Acad. Sci. 85:9729-9732 (1988).

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