Transgenic mice depleted in a mature lymphocytic cell-type

Details Transgenic mice depleted in a mature lymphocytic cell-type Transgenic mice depleted in a mature lymphocytic cell-type

1995-05-30

1997-01-07

Chambers, Jasemine C.

Multicellular living organisms and unmodified parts thereof and

Nonhuman animal

800DIG1, 4351723, 935111, C12N 1500

Patent

active

055916694

ABSTRACT:
Transgenic mice having a phenotype characterized by the substantial depletion of a mature lymphocytic cell type otherwise naturally occurring in the species from which the transgenic mouse is derived. The phenotype is conferred in the transgenic mouse by a transgene contained in at least the precursor stem cell of the lymphocytic cell type which is depleted. The transgene comprised is a DNA sequence encoding a lymphatic polypeptide variant which inhibits maturation of the lymphocytic cell type.

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