Transgenic mice containing stefin homolog protease inhibitor...

Multicellular living organisms and unmodified parts thereof and – Method of using a transgenic nonhuman animal in an in vivo...

Reexamination Certificate

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C800S008000, C800S018000, C800S021000

Reexamination Certificate

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06943277

ABSTRACT:
The present invention relates to transgenic animals, as well as compositions and methods relating to the characterization of gene function. Specifically, the present invention provides transgenic mice comprising mutations in a stefin homolog gene. Such transgenic mice are useful as models for disease and for identifying agents that modulate gene expression and gene function, and as potential treatments for various disease states and disease conditions.

REFERENCES:
patent: WO 97/14797 (1997-04-01), None
patent: WO 98/54307 (1998-12-01), None
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Tsui, F. W. L. et al.,Genomics, 15(3):507-514 (1993), “Molecular Characterization and Mapping of Murine Genes Encoding Three Members of the Stefin Family of Cysteine Proteinase Inhibitors”.
F. Tsui et al, “Mouse Cysteine Proteinase Inhibitor (MS2) mRNA Sequence” Database EMBL Online, May 18, 1998, retrieved from E.B.I., Hinxton, U.K., Database Accession No. M92418 (XP002212903), 1 page.
L. Pennacchio et al., “Progressive Ataxia, Myoclonic Epilepsy and Cerebellar Apoptosis in Cystatin B-Deficient Mice” Nature Genetics, vol. 20, Nov. 1998, pp. 251-258.
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