Multicellular living organisms and unmodified parts thereof and – Method of using a transgenic nonhuman animal in an in vivo...
Reexamination Certificate
2005-09-13
2005-09-13
Falk, Anne-Marie (Department: 1632)
Multicellular living organisms and unmodified parts thereof and
Method of using a transgenic nonhuman animal in an in vivo...
C800S008000, C800S018000, C800S021000
Reexamination Certificate
active
06943277
ABSTRACT:
The present invention relates to transgenic animals, as well as compositions and methods relating to the characterization of gene function. Specifically, the present invention provides transgenic mice comprising mutations in a stefin homolog gene. Such transgenic mice are useful as models for disease and for identifying agents that modulate gene expression and gene function, and as potential treatments for various disease states and disease conditions.
REFERENCES:
patent: WO 97/14797 (1997-04-01), None
patent: WO 98/54307 (1998-12-01), None
Sasaki et al., Characterization of gene expression in mouse blastocyst using single-pass sequencing of 3995 clones, 1998, Genomics, vol. 49, pp. 167-179.
Jacks et al., Effects of an Rb mutation in the mouse, 1992, Nature, vol. 359, pp. 295-300.
Capecchi, The new mouse genetics: Altering the genome by gene targeting, 1989, TIG, vol. 5, pp. 70-76.
Sigmund, Viewpoint: Are studies in genetically altered mice out of control?, 2000, Arterioscler Thromb. Vasc. Biol., vol. 20, pp. 1425-1429.
Wall, Transgenic livestock: Progress and prospects for the future, 1996, Theriogenology, vol. 45, pp. 57-68.
Bradley et al., Modifying the mouse: design and desire, 1992, Bio/Technology, vol. 10, pp. 534-539.
Campbell et al., Totipotency or multipotentiality of cultured cells: Applications and progress, 1997, vol. 47, pp. 63-72.
Mullins et al., Perspective series: Molecular medicine in genetically engineered animals, 1996, J. Clin. Invest., vol. 97, pp. 1557-1560.
Pennacchio, L. A. et al.,Nature Genetics, 20(3):251-258 (1998), “Progressive ataxia, myoclonic epilepsy and cerebellar apoptosis in cystatin B-deficient mice”.
Tsui, F. W. L. et al.,Genomics, 15(3):507-514 (1993), “Molecular Characterization and Mapping of Murine Genes Encoding Three Members of the Stefin Family of Cysteine Proteinase Inhibitors”.
F. Tsui et al, “Mouse Cysteine Proteinase Inhibitor (MS2) mRNA Sequence” Database EMBL Online, May 18, 1998, retrieved from E.B.I., Hinxton, U.K., Database Accession No. M92418 (XP002212903), 1 page.
L. Pennacchio et al., “Progressive Ataxia, Myoclonic Epilepsy and Cerebellar Apoptosis in Cystatin B-Deficient Mice” Nature Genetics, vol. 20, Nov. 1998, pp. 251-258.
F. Tsui et al., “Molecular Characterization and Mapping of Murine Genes Encoding Three Members of the Stefin Family of Cysteine Proteinase Inhibitors” Genomics, vol. 15, pp. 507-514 (1993).
Burke John E.
Deltagen Inc.
Falk Anne-Marie
Sullivan Daniel M
LandOfFree
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