Multicellular living organisms and unmodified parts thereof and – Nonhuman animal – Transgenic nonhuman animal
Reexamination Certificate
2005-02-22
2005-02-22
Falk, Anne-Marie (Department: 1636)
Multicellular living organisms and unmodified parts thereof and
Nonhuman animal
Transgenic nonhuman animal
C800S025000
Reexamination Certificate
active
06858772
ABSTRACT:
The present invention relates to transgenic animals, as well as compositions and methods relating to the characterization of gene function. Specifically, the present invention provides transgenic mice comprising mutations in the magnesium-dependent protein phosphatase gene. Such transgenic mice are useful as models for disease and for identifying agents that modulate gene expression and gene function, and as potential treatments for various disease states and disease conditions.
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Mansour et a., Disruption of the proto-oncogene int-2 in mouse embryo-derived stem cells: a general strategy for targeting mutations to non-selectable genes, 1988, Nature, vol. 336, pp. 348-352.*
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Kato et al., The cDNA sequence encoding mouse Mg2+ dependent protein phosphatase alpha, 1994, Gene, vol. 145, pp. 311-312.
Deltagen Inc.
Driscoll Robert J.
Falk Anne-Marie
Qian Celine
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