Transgenic mice containing a nucleic acid encoding tumor necrosi

Details Transgenic mice containing a nucleic acid encoding tumor necrosi Transgenic mice containing a nucleic acid encoding tumor necrosi

1997-03-14

1999-06-29

Crouch, Deborah

Multicellular living organisms and unmodified parts thereof and

Nonhuman animal

Transgenic nonhuman animal

800 3, 800 8, 800 9, 800 13, 800 14, C12N 500, G01N 3300

Patent

active

059171235

ABSTRACT:
The present invention provides transgenic nonhuman mammals that exhibit elevated levels of tumor necrosis factor alpha in myocardium relative to nontransgenic control mammals, and methods for making transgenic non-human mammals. The invention further provides a method for identifying agents useful in the treatment and prevention of cardiac dysfunction.

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