Transgenic mice containing a disrupted p53 gene

Details Transgenic mice containing a disrupted p53 gene Transgenic mice containing a disrupted p53 gene

1994-07-21

1996-10-29

Stone, Jacqueline M.

Multicellular living organisms and unmodified parts thereof and

Nonhuman animal

424 91, C12N 500, C12N 1500, A61K 4900

Patent

active

055698247

ABSTRACT:
A desired non-human animal or an animal cell or human cell which contains a predefined, specific and desired alteration in at least one of its two p53 chromosomal alleles, such that at least one of these alleles contains a mutation which alters the expression of the allele, and the other of the alleles expresses either a normal p53 gene product, or comprises an identical or different p53 mutation.

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