Organic compounds -- part of the class 532-570 series – Organic compounds – Carbohydrates or derivatives
Reexamination Certificate
2000-11-17
2010-02-09
Woitach, Joseph (Department: 1633)
Organic compounds -- part of the class 532-570 series
Organic compounds
Carbohydrates or derivatives
C800S003000, C800S013000, C800S014000, C800S018000, C435S325000
Reexamination Certificate
active
07659387
ABSTRACT:
The present invention relates to an isolated Period 1 (Per1) promoter DNA inducing rhythmical expression of a gene operably linked thereto. This invention also provides a DNA comprising a Period 1 promoter DNA and a gene operably linked thereto, the gene being under the regulation of the promoter DNA. The present invention further provides transformants and transgenic mammals into which the DNA has been introduced. The transformants and transgenic mammals are useful in the screening of pharmaceutical drugs against diseases and disorders pertaining to the circadian rhythm.
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Abe Michikazu
Sakaki Yoshiyuki
Takahashi Ri-ichi
Tei Hajime
Yamazaki Shin
Beattie, Esq. Ingrid A.
Hill Kevin K.
Kozakiewicz, Esq. Cynthia
Mintz Levin Cohn Ferris Glovsky and Popeo P.C.
Mitsubishi Pharma Corporation
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