Multicellular living organisms and unmodified parts thereof and – Nonhuman animal – Transgenic nonhuman animal
Reexamination Certificate
2005-10-14
2010-10-26
Wehbe, Anne Marie S (Department: 1633)
Multicellular living organisms and unmodified parts thereof and
Nonhuman animal
Transgenic nonhuman animal
C800S006000, C800S021000
Reexamination Certificate
active
07820877
ABSTRACT:
The present invention relates to transgenic non-human animals that are engineered to contain human immunoglobulin gene loci. In particular, animals in accordance with the invention possess human Ig loci that include plural variable (VHand Vκ) gene regions. Advantageously, the inclusion of plural variable region genes enhances the specificity and diversity of human antibodies produced by the animal. Further, the inclusion of such regions enhances and reconstitutes B-cell development to the animals, such that the animals possess abundant mature B-cells secreting extremely high affinity antibodies.
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Green Larry
Jakobovits Aya
Klapholz Sue
Kucherlapati Raju
Mendez Michael J.
Amgen Fremont Inc.
Doss Raymond M.
Gunnison Jane T.
Ropes & Gray LLP
Wehbe Anne Marie S
LandOfFree
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