Multicellular living organisms and unmodified parts thereof and – Nonhuman animal – Transgenic nonhuman animal
Reexamination Certificate
2006-06-20
2006-06-20
Wehbe′, Anne M. (Department: 1632)
Multicellular living organisms and unmodified parts thereof and
Nonhuman animal
Transgenic nonhuman animal
C800S013000, C800S006000
Reexamination Certificate
active
07064244
ABSTRACT:
The present invention relates to transgenic non-human animals that are engineered to contain human immunoglobulin gene loci. In particular, animals in accordance with the invention possess human Ig loci that include plural variable (VHand Vκ) gene regions. Advantageously, the inclusion of plural variable region genes enhances the specificity and diversity of human antibodies produced by the animal. Further, the inclusion of such regions enhances and reconstitutes B-cell development to the animals, such that the animals possess abundant mature B-cells secreting extremely high affinity antibodies.
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Green Larry
Jakobovits Aya
Klapholz Susan
Kucherlapati Raju
Mendez Michael J
Abgenix, Inc.
Fish & Neave IP Group Ropes & Gray LLP
Gunnison Jane
Pazdera R. Minako
Wehbe′ Anne M.
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