Transgenic luciferase mouse

Details Transgenic luciferase mouse Transgenic luciferase mouse

2006-05-09

2006-05-09

Crouch, Deborah (Department: 1632)

Multicellular living organisms and unmodified parts thereof and

Nonhuman animal

C800S003000, C800S021000

Reexamination Certificate

active

07041869

ABSTRACT:
The present invention provides a transgenic animal expressing the reporter gene, luciferase, driven by a promoter (e.g. the E2F1 promoter) that acts as a sensor of cell cycle. The luciferase substrate, luciferin, emits light when metabolized, and the light is transmitted through mammalian tissues. Therefore, the transgenic animal model of the present invention allows for monitoring of areas of major cell cycle activity, a characteristic of cancer cells, under adequate visualization conditions. These transgenic animals are useful as in vivo models for testing preventative measures for cancer as well as for testing novel therapeutic modalities.

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