Transgenic fish and β-catenin signaling pathway model

Details Transgenic fish and β-catenin signaling pathway model Transgenic fish and β-catenin signaling pathway model

2008-01-01

2008-01-01

Sullivan, Daniel M (Department: 1636)

Multicellular living organisms and unmodified parts thereof and

Nonhuman animal

Transgenic nonhuman animal

C435S320100, C800S003000, C800S021000

Reexamination Certificate

active

10679191

ABSTRACT:
The present invention is directed a Lef1/β-catenin-dependent reporter and to transgenic fish containing this reporter. The present invention is also directed to the use of the reporter and the transgenic fish as a model for the β-catenin signaling pathway. The model is useful for identifying genes in the β-catenin signaling pathway and for identifying drugs that can modulate the β-catenin signaling pathway. Such drugs are useful for treating or preventing melanoma, colorectal cancer and osteoporosis, among other disease conditions.

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