Transgenic fish and vectors therefor

Details Transgenic fish and vectors therefor Transgenic fish and vectors therefor

1994-10-20

1999-12-07

Campell, Bruce R.

Multicellular living organisms and unmodified parts thereof and

Nonhuman animal

Transgenic nonhuman animal

800 21, 435325, 536 2351, 536 241, C12N 500, C12N 1500, C07H 2104

Patent

active

059986972

ABSTRACT:
Sockeye salmon growth hormone genes Types 1 and 2, and sockeye histone and metallothionein gene promoters have been isolated and sequenced. Terminator sequences for the growth hormone gene have been found. Vectors containing these promoter and terminator sequences (and intermediate sequences) have been prepared and used to transform fish egg cells. Transformed fish egg cells have been grown into transgenic fish. In the case of inserted full-length growth hormone gene, both accelerated growth and early smoltification were observed. An aspect found beneficial is to combine homologous fish metallothionein or histone gene promoter with fish gene, preferably growth hormone gene, terminator in the same vector, for preparing transgenic fish.

REFERENCES:
patent: 5545808 (1996-08-01), Hew et al.
J. Watson et al., The Molecular Biology of the Gene, Benjamin Cummings Publ. Co., Menlo Park CA ('87), pp. 716-717.
R. Guyomand et al., Biochimie 71:857-63 ('89).
T. Chen et al, Transgenic Models in Med. & Agric. Wiley-Liss, Inc. ('90), pp. 127-139.
Z. Liu et al. Bio/Technology 8:1268-72 ('90).
M. Zaffarvllah et al. Mol. Cell. Biol. 8(10):4469-76, ('88).
W. Connec et al. J. Mol. Evol. 20:236-50 ('84).
B. Johansen et al. Gene 77:317-24 ('89).
L. Gonzalez--Villasenoc et al., Gene 65:239-246 ('88).
I. Guthrie et al. N. Am. J. Fish Man AG. (188) 8(4):442-54.
J-K. Lu et al. Mol. Marine Biol. & Biotech. (192) 1(4/5):366-75.
Seq. Search result--comparing SEQID #2 to Genbank Acc #M22487.
Seq. Search result--comparing SEQID #1 to Genbank Acc #X01064.
B. Cavari et al., Fish Physiology and Biochemistry, vol. 11, No. 1-6 pp. 345-352 (1993).
S.J. Du et al., Bio/Technology, vol. 10, pp. 176-181 (1992).

Affiliated with

Also associated with

Rating

Transgenic fish and vectors therefor does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Transgenic fish and vectors therefor, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Transgenic fish and vectors therefor will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-825940