Transgenic Drosophila having a disrupted Parkin gene and...

Details Transgenic Drosophila having a disrupted Parkin gene and... Transgenic Drosophila having a disrupted Parkin gene and...

2005-09-13

2005-09-13

Crouch, Deborah (Department: 1632)

Multicellular living organisms and unmodified parts thereof and

Nonhuman animal

Transgenic nonhuman animal

C800S003000, C800S012000

Reexamination Certificate

active

06943278

ABSTRACT:
The present invention relates to animal models for neuronal function, e.g., spontaneous changes in motor ability related to neuronal degeneration. For example, the present invention provides aDrosophila melanogastermodel for Parkinson's disease. The present invention also provides methods for generating genetically based neuronal disease models, identifying genes that affect neuronal function and methods for identifying compounds having activity with respect to neurological function.

REFERENCES:
patent: 1081225 (2001-03-01), None
Le Bourg et al. Hyypergravity, Aging and Longevity inDrosophila melanogaster. Comp. Biochem. Physiol. 1993, vol. 105A, No. 3, pp. 389-396.
Giasson and Lee, Neuron 31:885 (2001).
Dawson, Cell 101:115 (2000).
Feany and Bender, Nature 404:394 (2000).
Muqit and Feany, Nat. Rev. Neurosci., 3:237 (2002).
Beal, Nat. Rev. Neurosci., 2:325 (2001).
Auluck et al., Science 295:865 (2002).

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