Transgenic, cross-linked hemoglobin

Details Transgenic, cross-linked hemoglobin Transgenic, cross-linked hemoglobin

1993-07-30

1997-03-11

Wax, Robert A.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

435 696, 435 697, 4351723, 514 6, 530385, A61K 3800, C12P 2106, C07K 100, C07K 200

Patent

active

056101376

ABSTRACT:
Transgenic, recombinantly cross-linked polymeric human hemoglobins suitable as cell-free blood substitutes have been produced. A plurality of DNA constructs have been designed for efficient expression of modified human hemoglobins in the erythrocytes of the non-human transgenic animals. Substantially pure, non-immunogenic, artificial human hemoglobins are then easily obtained from the erythroid cells of the transgenic animals.

REFERENCES:
patent: 4861867 (1989-08-01), Estep
patent: 5028588 (1991-07-01), Hoffman et al.
patent: 5115100 (1992-05-01), Wu et al.
International Search Report for PCT/US91/09624 dated Apr. 10, 1992.
Gould et al., Annals of Surgery, 211:394, 1991.
Behringer et al., Science, 245: 971, 1989.
Matsumura et al., Proceedings of the National Academy of Science 86:6562-6566, 1989.
Moss et al., Biomat., Art. Cells, Art. Org. 4.,16:57-69, 1988.
Snyder et al., Proceedings of the National Academy of Science, 84:7280-7284, 1987.
Bunn et al., W. B. Saunders Co., Philadelphia pp. 13-35 and 381-451, 1986.
Tondo et al., An Acad. Brasil. Cienc. 57:498, 1985.
Nagai et al., Proc. Natl. Acad. Sci. USA, 82:7252-7255, 1985.
Bonaventura et al., Science, 158:800, 1967.

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