Multicellular living organisms and unmodified parts thereof and – Nonhuman animal – Transgenic nonhuman animal
Reexamination Certificate
2003-05-19
2008-08-19
Crouch, Deborah (Department: 1632)
Multicellular living organisms and unmodified parts thereof and
Nonhuman animal
Transgenic nonhuman animal
C800S005000, C800S006000, C800S025000
Reexamination Certificate
active
07414170
ABSTRACT:
The invention features novel methods for the production of large quantities of xenogenous antibodies, such as human antibodies. Preferably, this result is effected by inactivation of IgM heavy chain expression and, optionally, by inactivation of Ig light chain expression, and by the further introduction of an artificial chromosome which results in the expression of xenogenous antibodies (e.g., non-bovine antibodies), preferably human antibodies.
REFERENCES:
patent: 4797356 (1989-01-01), Brandt et al.
patent: 4847081 (1989-07-01), Rice
patent: 4873316 (1989-10-01), Meade et al.
patent: 4959317 (1990-09-01), Sauer
patent: 4994384 (1991-02-01), Prather et al.
patent: 5021244 (1991-06-01), Spaulding
patent: 5057420 (1991-10-01), Massey
patent: 5096822 (1992-03-01), Rosenkrans, Jr. et al.
patent: 5160312 (1992-11-01), Voelkel
patent: 5175384 (1992-12-01), Krimpenfort et al.
patent: 5213979 (1993-05-01), First et al.
patent: 5320952 (1994-06-01), Deutch et al.
patent: 5346990 (1994-09-01), Spaulding
patent: 5374544 (1994-12-01), Schwartz et al.
patent: 5434066 (1995-07-01), Bebee et al.
patent: 5434340 (1995-07-01), Krimpenfort et al.
patent: 5453366 (1995-09-01), Sims et al.
patent: 5464764 (1995-11-01), Capecchi et al.
patent: 5470560 (1995-11-01), Martin, Jr.
patent: 5482856 (1996-01-01), Fell, Jr. et al.
patent: 5487992 (1996-01-01), Capecchi et al.
patent: 5496720 (1996-03-01), Susko-Parrish et al.
patent: 5527674 (1996-06-01), Guerra et al.
patent: 5545806 (1996-08-01), Lonberg et al.
patent: 5545807 (1996-08-01), Surani et al.
patent: 5565350 (1996-10-01), Kmiec
patent: 5565362 (1996-10-01), Rosen
patent: 5569825 (1996-10-01), Lonberg et al.
patent: 5583016 (1996-12-01), Villeponteau et al.
patent: 5591669 (1997-01-01), Krimpenfort et al.
patent: 5612205 (1997-03-01), Kay et al.
patent: 5614396 (1997-03-01), Bradley et al.
patent: 5618686 (1997-04-01), Kojima et al.
patent: 5625126 (1997-04-01), Lonberg et al.
patent: 5627059 (1997-05-01), Capecchi et al.
patent: 5631153 (1997-05-01), Capecchi et al.
patent: 5633076 (1997-05-01), DeBoer et al.
patent: 5633425 (1997-05-01), Lonberg et al.
patent: 5639457 (1997-06-01), Brem et al.
patent: 5652373 (1997-07-01), Reisner
patent: 5654182 (1997-08-01), Wahl et al.
patent: 5660997 (1997-08-01), Spaulding
patent: 5661016 (1997-08-01), Lonberg et al.
patent: 5677177 (1997-10-01), Wahl et al.
patent: 5679523 (1997-10-01), Li et al.
patent: 5695977 (1997-12-01), Jurka
patent: 5698763 (1997-12-01), Weissmann et al.
patent: 5721367 (1998-02-01), Kay et al.
patent: 5733730 (1998-03-01), De Lange
patent: 5741957 (1998-04-01), Deboer et al.
patent: 5750172 (1998-05-01), Meade et al.
patent: 5756325 (1998-05-01), Kmiec
patent: 5763240 (1998-06-01), Zarling et al.
patent: 5770422 (1998-06-01), Collins
patent: 5770429 (1998-06-01), Lonberg et al.
patent: 5776744 (1998-07-01), Glazer et al.
patent: 5780009 (1998-07-01), Karatzas et al.
patent: 5780296 (1998-07-01), Holloman et al.
patent: 5789215 (1998-08-01), Berns et al.
patent: 5789650 (1998-08-01), Lonberg et al.
patent: 5789655 (1998-08-01), Prusiner et al.
patent: 5801030 (1998-09-01), McVey et al.
patent: 5814318 (1998-09-01), Lonberg et al.
patent: 5821117 (1998-10-01), Sandrin et al.
patent: 5827690 (1998-10-01), Meade et al.
patent: 5830698 (1998-11-01), Reff et al.
patent: 5837857 (1998-11-01), Villeponteau et al.
patent: 5843643 (1998-12-01), Ratner
patent: 5843754 (1998-12-01), Susko-Parrish et al.
patent: 5849991 (1998-12-01), d'Apice et al.
patent: 5849992 (1998-12-01), Meade et al.
patent: 5874299 (1999-02-01), Lonberg et al.
patent: 5876979 (1999-03-01), Andrews et al.
patent: 5877397 (1999-03-01), Lonberg et al.
patent: 5891698 (1999-04-01), Prieto et al.
patent: 5945577 (1999-08-01), Stice et al.
patent: 5952222 (1999-09-01), Rosenkrans, Jr. et al.
patent: 6011197 (2000-01-01), Strelchenko et al.
patent: 6023010 (2000-02-01), Krimpenfort et al.
patent: 6030833 (2000-02-01), Seebach et al.
patent: 6054632 (2000-04-01), Reid
patent: 6066719 (2000-05-01), Zapata
patent: 6074853 (2000-06-01), Pati et al.
patent: 6077710 (2000-06-01), Susko-Parrish et al.
patent: 6091001 (2000-07-01), Jakobovits et al.
patent: 6133503 (2000-10-01), Scheffler
patent: 6147276 (2000-11-01), Campbell et al.
patent: 6153428 (2000-11-01), Gustafsson et al.
patent: 6166288 (2000-12-01), Diamond et al.
patent: 6183993 (2001-02-01), Boyce et al.
patent: 6194202 (2001-02-01), Susko-Parrish et al.
patent: 6204061 (2001-03-01), Capecchi et al.
patent: 6204431 (2001-03-01), Prieto et al.
patent: 6252133 (2001-06-01), Campbell et al.
patent: 6258998 (2001-07-01), Damiani et al.
patent: 6271436 (2001-08-01), Piedrahita et al.
patent: 6300129 (2001-10-01), Lonberg et al.
patent: 6395958 (2002-05-01), Strelchenko et al.
patent: 6753457 (2004-06-01), Wangh et al.
patent: 7074983 (2006-07-01), Robl et al.
patent: 2002/0001842 (2002-01-01), Chapman
patent: 2002/0012660 (2002-01-01), Colman et al.
patent: 2002/0069423 (2002-06-01), Good et al.
patent: 2002/0108132 (2002-08-01), Rapp
patent: 2002/0194635 (2002-12-01), Dunne et al.
patent: 2005/0097627 (2005-05-01), Robl et al.
patent: 2006/0041945 (2006-02-01), Robl et al.
patent: 2006/0117394 (2006-06-01), Robl et al.
patent: 2006/0117395 (2006-06-01), Robl et al.
patent: 2006/0130157 (2006-06-01), Wells et al.
patent: 0773288 (1997-05-01), None
patent: 0546073 (1997-09-01), None
patent: 0843961 (1998-05-01), None
patent: 1106061 (2001-06-01), None
patent: WO92/03918 (1992-03-01), None
patent: WO93/10227 (1993-05-01), None
patent: WO94/02602 (1994-02-01), None
patent: WO95/23868 (1995-09-01), None
patent: WO95/33828 (1995-12-01), None
patent: WO96/33735 (1996-10-01), None
patent: WO97/07668 (1997-03-01), None
patent: WO97/07669 (1997-03-01), None
patent: WO97/07671 (1997-03-01), None
patent: WO97/13852 (1997-04-01), None
patent: WO98/14593 (1998-04-01), None
patent: WO98/24884 (1998-06-01), None
patent: WO98/24893 (1998-06-01), None
patent: WO98/30683 (1998-07-01), None
patent: WO98/37183 (1998-08-01), None
patent: WO98/39416 (1998-09-01), None
patent: WO99/21415 (1999-05-01), None
patent: WO99/60108 (1999-11-01), None
patent: WO 00/10383 (2000-03-01), None
patent: WO 00/42174 (2000-07-01), None
patent: WO 00/46251 (2000-08-01), None
patent: WO 00/51424 (2000-09-01), None
patent: WO 00/67568 (2000-11-01), None
patent: WO 00/67569 (2000-11-01), None
patent: WO 00/74477 (2000-12-01), None
patent: WO 01/23541 (2001-04-01), None
patent: WO 01/30992 (2001-05-01), None
patent: WO 01/35735 (2001-05-01), None
patent: WO 01/73107 (2001-10-01), None
patent: WO 02/12437 (2002-02-01), None
patent: WO 02/051997 (2002-07-01), None
patent: WO 02/070648 (2002-09-01), None
patent: WO 02/079416 (2002-10-01), None
Clark et al. A Future for Transgenic Livestock. Nature Reviews: Genetics: Oct. 2003, vol. 4, pp. 825-833.
Niemann et al. Transgeic Farm Animals: Present and Future. Rev. Sci, Tech. Off. Int. Spiz. 2005, vol. 24, pp. 285-298.
Wheeler et al. Transgenic Technology and Applications in Swine. Theriogenology. 2001, vol. 56, pp. 1345-1369.
Prelle et al. Pluripotent Stem Cells—Models of Embryonic Development, Tool for Gene Targeting, and Basis of Cell Therapy. Anat. Histol. Embryol. 2002, vol. 31, pp. 169-186.
Denning, C. et al. Gene Targeting in Primary Fetal Fibroblasts from Sheep and Pig. Cloning and Stem Cells. 2001, vol. 3, pp. 221-231.
Pennisi and Vogel. Cloning: A Hard Act to Follow. Science. Jun. 9, 2000, vol. 288, pp. 1722-1727.
Campbell, K.H.S. Nuclear Transfer in Farm Animal Species. Seminars in Cell & Develop. Biol. 1999, vol. 19, pp. 245-252.
Aheam et al., “Disruption of theCr2Locus Results in a Reduction in B-1a Cells and in an Impaired B Cell Response to T-Dependent Antigen,”Immunity4:251-262 (1996).
Burke et al., “A Cell Free System to Study Reassembly of the Nuclear Envelope at the End of Mitosis,”Cell44:639-652 (1986).
Cibelli et al., “Bovine Chimeric Offspring Produced By Transgenic Embryonic Stem Cells Generated From Somatic Cell Nuclear Transfer Embryos,”Theriogenology49:236 (1998).
Cibelli et al., “Clone
Goldsby Richard A.
Ishida Isao
Kasinathan Poothappillai
Kuroiwa Yoshimi
Osborne Barbara
Clark & Elbing LLP
Crouch Deborah
Kirin Beer Kabushiki Kaisha
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