Multicellular living organisms and unmodified parts thereof and – Nonhuman animal – Transgenic nonhuman animal
Reexamination Certificate
2008-09-05
2010-10-05
Crouch, Deborah (Department: 1632)
Multicellular living organisms and unmodified parts thereof and
Nonhuman animal
Transgenic nonhuman animal
C800S024000, C435S325000
Reexamination Certificate
active
07807863
ABSTRACT:
The invention provides cloned transgenic ungulates (e.g., bovines) in which prion protein activity is reduced by one or more genetically engineered mutations. Desirably, these transgenic bovines are also genetically modified to express xenogenous (e.g., human) antibodies. Because of their resistance to prion-related diseases such as bovine spongiform encephalopy (also known as mad cow disease), these bovines are a safer source of human antibodies for pharmaceutical uses and a safer source of agricultural products.
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Ishida Isao
Kuroiwa Yoshimi
Robl James M.
Tomizuka Kazuma
Clark & Elbing LLP
Crouch Deborah
Kyowa Hakko Kirin Co., Ltd.
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