Multicellular living organisms and unmodified parts thereof and – Nonhuman animal
Patent
1995-06-05
1998-04-21
Crouch, Deborah
Multicellular living organisms and unmodified parts thereof and
Nonhuman animal
800DIG1, 435 691, 935 60, 935 63, C12N 500, C12N 1500, C12P 2106
Patent
active
057419574
ABSTRACT:
A transgenic bovine is disclosed whose somatic and germ cells contain a transgene, wherein the transgene comprising a mammary gland specific promoter, a mammary gland specific enhancer, a DNA sequence encoding a signal sequence functional in bovine mammary gland secretory cells and a DNA sequence encoding a heterologous polypeptide of interest wherein the transgenic bovine expresses the transgene such that the polypeptide of interest is detectable in milk produced by the transgenic bovine.
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DeBoer Herman A.
Heyneker Herbert L.
Krimpenfort Paul J. A.
Lee Sang He
Pieper Frank
Crouch Deborah
Pharming B.V.
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