Multicellular living organisms and unmodified parts thereof and – Nonhuman animal
Patent
1988-07-12
1992-06-02
Weimar, Elizabeth C.
Multicellular living organisms and unmodified parts thereof and
Nonhuman animal
800DIG1, 4351723, C12N 1500
Patent
active
H00010650
ABSTRACT:
A transgenic avian line, which is resistant to infection by avian leukosis virus (ALV), subgroup A, has been produced. The line was discovered as a chance event occurring in a program of infecting embryonic chickens with a recombinant ALV virus, selecting individuals assayed to be positive for genomic insertion of proviral sequences, and backcrossing to the original line to obtain G1 progeny demonstrating stable inheritance of the inserts. Of at least three proviral inserts defective for ALV production, one was found to be capable of expressing in the cell membrane subgroup A envelope glycoprotein which specifically interferes with infection by subgroup A virus. This insert represents an artificially introduced dominant gene for ALV disease resistance. Through an appropriate breeding program, a line of chickens homozygous for this gene has been obtained.
REFERENCES:
D. S. Falconer, Introduction to Quantitative Genetics, Preface, Chapter 3, pp. 48-49, (1960), The Ronald Press Company, New York, N.Y.
L. B. Crittenden et al., "Gene Insertion: Current Progress and Long-Term Goals", Avian Dis., 30(1):43-46 (1985).
L. B. Crittenden et al., "Genetic Engineering to Improve Resistance to Viral Diseases of Poultry: A Model for Application to Livestock Improvement", Can. J. Anim. Sci., 65:553-562 (Sep. 1985).
Donald W. Salter et al., "Gene Insertion into the Chicken Germ Line by Retroviruses", Poult. Sci., 65:1445-1458 (1986).
D. W. Salter et al., "Chickens Transgenic for a Defective Recombinant Avian Leukosis Proviral Insert Express Subgroup A Envelope Glycoprotein", Poult. Sci. Abstracts of Papers, 66:170 (Jul. 1987).
Crittenden Lyman B.
Salter Donald W.
Chambers Jasemine C.
Fado John D.
Ribando Curtis P.
Silverstein M. Howard
The United States of America as represented by the Secretary of
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