Multicellular living organisms and unmodified parts thereof and – Nonhuman animal – Transgenic nonhuman animal
Patent
1998-06-25
2000-02-22
Campell, Bruce R.
Multicellular living organisms and unmodified parts thereof and
Nonhuman animal
Transgenic nonhuman animal
800 3, 800 8, 800 9, 800 13, 800 14, 435440, 435455, C12N 1500
Patent
active
060282452
ABSTRACT:
The present invention relates to transgenic, non-human animals overexpressing a MDM2 gene. These animals model MDM2 over-expression associated with human tumors, display a major phenotype characterized by the severe skin disorder ichthyosis, and are useful for identifying compounds for the treatment of human disease. Therefore, the invention also relates to methods of using the animals for identifying compounds effective for the treatment of diseases of the skin and respiratory tract, and to the compounds themselves.
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Alkhalaf Moussa
Tocque Bruno
Wasylyk Bohdan
Baker Anne-Marie
Campell Bruce R.
Institut National de la Sante et de la Recherche Medicale
Rhone-Poulenc Rorer SA
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