Transgenic animals for the determination of agents which stimula

Details Transgenic animals for the determination of agents which stimula Transgenic animals for the determination of agents which stimula

1997-05-22

2000-07-11

Campell, Bruce R.

Multicellular living organisms and unmodified parts thereof and

Nonhuman animal

Transgenic nonhuman animal

800 3, C12N 500, C12N 1500

Patent

active

060875542

ABSTRACT:
A vertebrate, non-human transgenic animal whose cells, both somatic and germinal, contain a recombinant genetic construction formed of a marker gene and a regulator region capable of being induced in the epidermis of said transgenic animal in response to hyperproliferative stimuli, the genetic construction of which has been introduced into the animal or into an antecessor of the animal in an embryonic stage. The genetic construction is induced also in the bulb of the hair in the phase of active growth or anagen. The said genetic construction consists of a marker gene characterized by the fact that it is easily detectable, under the control of the regulator region of the gene of the K6 keratin, this protein being characterized by its ability to be induced in the suprabasal layers of the epidermis in response to hyperproliferative stimuli both endogenous (tumors, cicatrization of wounds, diseases which, such as psoriasis, produce hyperproliferation, etc.) and exogenous (topical treatments with retinoic acid, TPA, etc.). Therefore, transgenic animals carrying this genetic construction in their genome are useful in the identification of physical, chemical or biological agents which lead to epidermal hyperproliferation and growth of the hair, or inhibit these processes.

REFERENCES:
A Fire et al (1990) Gene 93: 189-198.
RM Strojek et al (1988) Genetic Engineering:Principles and Methods. v. 10 pp. 221-246 Plenum Press.
M Blessing et al (1987) EMBO J 6:567-575.
C-K Jiang et al (1991) J. Investigative Dermatology 96:162-167.
M Blessing et al (1989) EMBO J. 8: 117-126.
M Abe et al (1990) J Cell Biol 111: 1197-1206.

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