Multicellular living organisms and unmodified parts thereof and – Method of using a transgenic nonhuman animal to manufacture...
Patent
1998-02-26
2000-11-21
Carlson, Karen Cochrane
Multicellular living organisms and unmodified parts thereof and
Method of using a transgenic nonhuman animal to manufacture...
800 3, 800 6, 435 691, 435 71, 4353201, 536 231, A01K 6700, C12P 2106, C07H 1700
Patent
active
061505838
ABSTRACT:
DNA constructs are provided of epitope-tagged proteins or protein fragments which are conveniently purified with immunoaffinity chromatography such as epitope-tagged prion proteins (PrP). Transgenic animals expressing an epitope-tagged protein are provided, including transgenic animals expressing epitope-tagged PrP. Methods for distinguishing between the conformational shapes of a protein and a convenient method for isolating a tagged protein by immunoaffinity chromatographic methods are provided.
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Cohen Fred E.
Prusiner Stanley B.
Scott Michael R.
Telling Glenn C.
Bozicevic Karl
Carlson Karen Cochrane
The Regents of the University of California
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