Transgenic animals deficient in endogenous .beta..sub.3 -adrener

Details Transgenic animals deficient in endogenous .beta..sub.3 -adrener Transgenic animals deficient in endogenous .beta..sub.3 -adrener

1996-05-09

1998-08-04

Chambers, Jasemine C.

Multicellular living organisms and unmodified parts thereof and

Nonhuman animal

4351723, 435 691, 4353201, 435 6, 435325, 424 92, C12N 500, C12N 1500, C12N 1509

Patent

active

057896542

ABSTRACT:
Disclosed a transgenic non-human mammal whose germ cells and somatic cells contain a knockout mutation in DNA encoding .beta..sub.3 -adrenergic receptor polypeptide.

REFERENCES:
patent: 5288607 (1994-02-01), Emorine et al.
Susulic et al., Journal of Cellular Biochemistry, Suppl. 18A, p. 172, 1994.
Bradley et al., Biotechnology, vol. 10, pp. 534-539, 1992.
Emorine et al., "Molecular Characterization of the Human .beta..sub.3 -Adrenergic Receptor", Science, 345:1118-1121.
Lowell et al., Nature 366:740-742, 1993.
Maffei et al., Proc. Natl. Acad. Sci. USA 92:6957-6960, 1995.
Revelli et al., Experientia 51,A30, 1995.
Susulic et al., Journal of Biological Chemistry 270:29483-29492, 1995.
Susulic et al., The Endocrine Society 77th Annual Meeting, Session S35 p. 36, 1996.

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