Transgenic animals capable of replicating hepatitis viruses and

Details Transgenic animals capable of replicating hepatitis viruses and Transgenic animals capable of replicating hepatitis viruses and

1998-01-07

2000-07-11

Hauda, Karen M.

Multicellular living organisms and unmodified parts thereof and

Nonhuman animal

Transgenic nonhuman animal

800 3, 800 25, C12N 1509, C12N 510, A61K 4900

Patent

active

060875569

ABSTRACT:
Transgenically modified animals which replicate hepatitis viruses are provided for use in evaluating virus-chemical and virus-drug interactions in chronic hepatitis infections.

REFERENCES:
Houdebine, L. "Production of pharmaceutical proteins from transgenic animals," J. of Biotechnology, vol. 34:269-287, 1994.
Wall, R.J. "Transgenic Livestock: Progress and Prospects for the Future," Theriogenology, vol. 45: 57-68, 1996.
Strojek and Wagner, "The Use of Transgenic Animal Techniques for Livestock Iprovement," Genetic Engineering: Principles and Methods, vol. 10: 221-246, 1988.
Kappel et al. "Regulating Gene Expression in Transgenic Animals," Current Opinion in Biotechnology, vol. 3: 548-553, 1992.
Paul, W.E. Fundamental Immunology. 3rd Edition. Raven Press, New York, New York, 1993.
Kawamura et al. Transgenic expression of hepatitis C virus structureal proteins, Hepatology, 24 (4Part 2), 263A, abstract 547, 47th Annual Meeting and Postgraduate Courses of the American Association for the Study of Liver Diseases, Nov. 8-12, Nov. 1996.
Huang et al. Gene Targeting Technology for Creating Transgenic Models of Lymphopoieses, vol. 43, No. 2: 156-159, Apr. 1993.

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