Multicellular living organisms and unmodified parts thereof and – Nonhuman animal – Transgenic nonhuman animal
Reexamination Certificate
2005-05-03
2005-05-03
Fredman, Jeffrey (Department: 1636)
Multicellular living organisms and unmodified parts thereof and
Nonhuman animal
Transgenic nonhuman animal
C800S004000, C800S015000, C800S016000, C800S017000, C800S018000, C800S021000, C800S025000, C435S069100, C435S320100, C435S325000, C435S455000, C523S001000, C523S001000
Reexamination Certificate
active
06888047
ABSTRACT:
The invention relates to recombinant DNA constructs, a method for producing a recombinant biologically active protein in vivo in the urine of a non-human mammal using a kidney-specific promoter, such as the uromodulin promoter, and the transgenic non-human mammals that serve as urine-based bioreactors for protein production.
REFERENCES:
patent: 5824543 (1998-10-01), Sun
patent: 6001646 (1999-12-01), Sun
patent: 6339183 (2002-01-01), Sun
patent: 0 653 154 (1995-03-01), None
patent: 9928463 (1999-06-01), None
patent: 0015772 (2000-03-01), None
Wood. Phenotype Assesment: Are you missing something? Comp. Med. 50(1): 12-15, 2000.*
Sigmund, Viewpoint: Are studies in genetically altered mice out of control? Arterioscler. Throm. Vasc. Biol. 20:1425-1429, 2000.*
Su et al Uromodulin and Tamm-horsfall protein induce human monocytes to secrete TNFa nd express tissue factor. J Immunolgy 158:3449-3436, 1997.*
Pursel VG et al, Expression and performance in transgenic pigs. J. Reprod. Fert. Sup 40: 235-245 1990.*
Lin J et al A tissue-specific promoter that can drive a foreign gene to express in the suprabasal urothelial cells of transgenic mice.PNAS 92:679-683, 1995.*
Zbikowska et al Uromodulin promoter directs high-level expression of biologically active human a1-antitypsin into mouse urine Biochem J 365:7-11, 2002.*
Jeanpierre et al., Chromosomal assignment of the uromodulin gene (UMOD) to 16p13.11,Cytogenet Cell Genet62: 185-187 (1993).
Kappel et al., Regulating gene expression in transgenic animals,Current Opinion in Biotechnology3:548-553 (1992).
Kerr et al., The bladder as a bioreactor: Urothelium production and secretion of growth hormone into urine,Nature Biotechnology16:75-79 (1998).
Su et al., Uromodulin and Tamm-Horsfall protein induce human monocytes to secrete TNF and express tissue factor,The American Association of Immunologists3449-3456 (1997).
Viville, Mouse genetic manipulation via homologous recombination,Transgenic Animals: Generation and Use307-321 (1997).
Wall, Transgenic livestock: progress and prospects for the future,Theriogenology45:57-68 (1996).
Zhong-Ting et al., Urothelium-specific expression of an oncogene in transgenic mice induced the formation of carcinoma in Situ and invasive transitional cell carcinoma,Cancer Research59:3512-3517 (1999).
Yu et al., Bovine and rodent Tamm-Horsfall protein (THP) genes: Cloning, structural analysis, and promoter identification,Gene Expression4:63-75 (1994).
Sun Tung-Tien
Wu Xue-Ru
Browdy and Neimark PLLC
Fredman Jeffrey
Kaushal Sumesh
New York University
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