Transgenic animals and uses thereof

Details Transgenic animals and uses thereof Transgenic animals and uses thereof

2005-04-21

2008-09-02

Woitach, Joseph (Department: 1633)

Multicellular living organisms and unmodified parts thereof and

Nonhuman animal

Transgenic nonhuman animal

C800S006000, C800S025000

Reexamination Certificate

active

07420099

ABSTRACT:
In general, the invention features genetically modified non-human mammals (e.g., bovines and other ungulates), and methods of making these mammals. In particular, the invention features transgenic ungulates having reduced levels of endogenous IgM heavy chain and/or prion protein.

REFERENCES:
patent: 4797356 (1989-01-01), Brandt et al.
patent: 4847081 (1989-07-01), Rice
patent: 4873316 (1989-10-01), Meade et al.
patent: 4959317 (1990-09-01), Sauer
patent: 4994384 (1991-02-01), Prather et al.
patent: 5021244 (1991-06-01), Spaulding
patent: 5057420 (1991-10-01), Massey
patent: 5096822 (1992-03-01), Rosenkrans, Jr. et al.
patent: 5160312 (1992-11-01), Voelkel
patent: 5175384 (1992-12-01), Krimpenfort et al.
patent: 5213979 (1993-05-01), First et al.
patent: 5320952 (1994-06-01), Deutch et al.
patent: 5346990 (1994-09-01), Spaulding
patent: 5374544 (1994-12-01), Schwartz et al.
patent: 5434066 (1995-07-01), Bebee et al.
patent: 5434340 (1995-07-01), Krimpenfort et al.
patent: 5453366 (1995-09-01), Sims et al.
patent: 5464764 (1995-11-01), Capecchi et al.
patent: 5470560 (1995-11-01), Martin, Jr.
patent: 5482856 (1996-01-01), Fell, Jr. et al.
patent: 5487992 (1996-01-01), Capecchi et al.
patent: 5496720 (1996-03-01), Susko-Parrish et al.
patent: 5527674 (1996-06-01), Guerra et al.
patent: 5545806 (1996-08-01), Lonberg et al.
patent: 5545807 (1996-08-01), Surani et al.
patent: 5565350 (1996-10-01), Kmiec
patent: 5565362 (1996-10-01), Rosen
patent: 5569825 (1996-10-01), Lonberg et al.
patent: 5583016 (1996-12-01), Villeponteau et al.
patent: 5591669 (1997-01-01), Krimpenfort et al.
patent: 5612205 (1997-03-01), Kay et al.
patent: 5614396 (1997-03-01), Bradley et al.
patent: 5618686 (1997-04-01), Kojima et al.
patent: 5625126 (1997-04-01), Lonberg et al.
patent: 5627059 (1997-05-01), Capecchi et al.
patent: 5631153 (1997-05-01), Capecchi et al.
patent: 5633076 (1997-05-01), DeBoer et al.
patent: 5633425 (1997-05-01), Lonberg et al.
patent: 5639457 (1997-06-01), Brem et al.
patent: 5652373 (1997-07-01), Reisner
patent: 5654182 (1997-08-01), Wahl et al.
patent: 5660997 (1997-08-01), Spaulding
patent: 5661016 (1997-08-01), Lonberg et al.
patent: 5677177 (1997-10-01), Wahl et al.
patent: 5679523 (1997-10-01), Li et al.
patent: 5695977 (1997-12-01), Jurka
patent: 5698763 (1997-12-01), Weissmann et al.
patent: 5721367 (1998-02-01), Kay et al.
patent: 5733730 (1998-03-01), De Lange
patent: 5741957 (1998-04-01), Deboer et al.
patent: 5750172 (1998-05-01), Meade et al.
patent: 5756325 (1998-05-01), Kmiec
patent: 5763240 (1998-06-01), Zarling et al.
patent: 5770422 (1998-06-01), Collins
patent: 5770429 (1998-06-01), Lonberg et al.
patent: 5776744 (1998-07-01), Glazer et al.
patent: 5780009 (1998-07-01), Karatzas et al.
patent: 5780296 (1998-07-01), Holloman et al.
patent: 5789215 (1998-08-01), Berns et al.
patent: 5789650 (1998-08-01), Lonberg et al.
patent: 5789655 (1998-08-01), Prusiner et al.
patent: 5801030 (1998-09-01), McVey et al.
patent: 5814318 (1998-09-01), Lonberg et al.
patent: 5821117 (1998-10-01), Sandrin et al.
patent: 5827690 (1998-10-01), Meade et al.
patent: 5830698 (1998-11-01), Reff et al.
patent: 5837857 (1998-11-01), Villeponteau et al.
patent: 5843643 (1998-12-01), Ratner
patent: 5843754 (1998-12-01), Susko-Parrish et al.
patent: 5849991 (1998-12-01), d'Apice et al.
patent: 5849992 (1998-12-01), Meade et al.
patent: 5874299 (1999-02-01), Lonberg et al.
patent: 5876979 (1999-03-01), Andrews et al.
patent: 5877397 (1999-03-01), Lonberg et al.
patent: 5891698 (1999-04-01), Prieto et al.
patent: 5945577 (1999-08-01), Stice et al.
patent: 5952222 (1999-09-01), Rosenkrans, Jr. et al.
patent: 6011197 (2000-01-01), Strelchenko et al.
patent: 6023010 (2000-02-01), Krimpenfort et al.
patent: 6030833 (2000-02-01), Seebach et al.
patent: 6054632 (2000-04-01), Reid
patent: 6066719 (2000-05-01), Zapata
patent: 6074853 (2000-06-01), Pati et al.
patent: 6077710 (2000-06-01), Susko-Parrish et al.
patent: 6091001 (2000-07-01), Jakobovits et al.
patent: 6133503 (2000-10-01), Scheffler
patent: 6147276 (2000-11-01), Campbell et al.
patent: 6153428 (2000-11-01), Gustafsson et al.
patent: 6166288 (2000-12-01), Diamond et al.
patent: 6183993 (2001-02-01), Boyce et al.
patent: 6194202 (2001-02-01), Susko-Parrish et al.
patent: 6204061 (2001-03-01), Capecchi et al.
patent: 6204431 (2001-03-01), Prieto et al.
patent: 6252133 (2001-06-01), Campbell et al.
patent: 6258998 (2001-07-01), Damiani et al.
patent: 6271436 (2001-08-01), Piedrahita et al.
patent: 6300129 (2001-10-01), Lonberg et al.
patent: 6395958 (2002-05-01), Strelchenko et al.
patent: 6753457 (2004-06-01), Wangh et al.
patent: 2002/0001842 (2002-01-01), Chapman
patent: 2002/0012660 (2002-01-01), Colman et al.
patent: 2002/0069423 (2002-06-01), Good et al.
patent: 2002/0108132 (2002-08-01), Rapp
patent: 2002/0194635 (2002-12-01), Dunne et al.
patent: 2003/0037347 (2003-02-01), Robl et al.
patent: 2004/0068760 (2004-04-01), Robl et al.
patent: 2004/0131620 (2004-07-01), Maeda et al.
patent: 2005/0097627 (2005-05-01), Robl et al.
patent: 2005/0183145 (2005-08-01), Goldsby et al.
patent: 2006/0117394 (2006-06-01), Robl et al.
patent: 2006/0117395 (2006-06-01), Robl et al.
patent: 2006/0130157 (2006-06-01), Wells et al.
patent: 0773288 (1997-05-01), None
patent: 0546073 (1997-09-01), None
patent: 0843961 (1998-05-01), None
patent: 1106061 (2001-06-01), None
patent: WO 92/03918 (1992-03-01), None
patent: WO 93/10227 (1993-05-01), None
patent: WO 94/02602 (1994-02-01), None
patent: WO 95/23868 (1995-09-01), None
patent: WO 95/33828 (1995-12-01), None
patent: WO 96/33735 (1996-10-01), None
patent: WO 97/07668 (1997-03-01), None
patent: WO 97/07669 (1997-03-01), None
patent: WO 97/07671 (1997-03-01), None
patent: WO 97/13852 (1997-04-01), None
patent: WO 98/14593 (1998-04-01), None
patent: WO 98/24884 (1998-06-01), None
patent: WO 98/24893 (1998-06-01), None
patent: WO 98/30683 (1998-07-01), None
patent: WO 98/37183 (1998-08-01), None
patent: WO 98/39416 (1998-09-01), None
patent: WO 99/21415 (1999-05-01), None
patent: WO 99/60108 (1999-11-01), None
patent: WO 00/10383 (2000-03-01), None
patent: WO 00/42174 (2000-07-01), None
patent: WO 00/46251 (2000-08-01), None
patent: WO 00/51424 (2000-09-01), None
patent: WO 00/67568 (2000-11-01), None
patent: WO 00/67569 (2000-11-01), None
patent: WO 00/74477 (2000-12-01), None
patent: WO 01/23541 (2001-04-01), None
patent: WO 01/30992 (2001-05-01), None
patent: WO 01/35735 (2001-05-01), None
patent: WO 01/73107 (2001-10-01), None
patent: WO 02/12437 (2002-02-01), None
patent: WO 02/051997 (2002-07-01), None
patent: WO 02/070648 (2002-09-01), None
patent: WO 02/079416 (2002-10-01), None
patent: WO 2004/044156 (2004-05-01), None
Yang, Springer Semin. Immun. 26:187-200; 2004.
Greiner et al. Stem Cell 16:166-177; 1998.
Ahearn et al., “Disruption of the Cr2 Locus Results in a Reduction in B-1a Cells and in an Impaired B Cell Response to T-Dependent Antigen,”Immunity4:251-262 (1996).
Burke et al., “A Cell Free System to Study Reassembly of the Nuclear Envelope at the End of Mitosis,”Cell44:639-652 (1986).
Cibelli et al., “Bovine Chimeric Offspring Produced By Transgenic Embryonic Stem Cells Generated From Somatic Cell Nuclear Transfer Embryos,”Theriogenology49:236 (1998).
Cibelli et al., “Cloned Transgenic Calves Produced from Nonquiescent Fetal Fibroblasts,”Science280:1256-1258 (1998).
Collas et al., “Lipophilic Organizing Structures of Sperm Nuclei Target Membrane Vesicle Binding and Are Incorporated into the Nuclear Envelope,”Dev. Biol.169:123-135 (1995).
Collas, “Sequential PKC- and Cdc2-Mediated Phosphorylation Events Elicit Zebrafish Nuclear Envelope Disassembly,”J. Cell Sci.112:977-987 (1999).
Collas et al., “The A-Kinase Anchoring Protein, AKAP95, Is A Multivalent Protein With A Key Role In Chromatin Condensation At Mitosis,”J. Cell Biol.147:1167-1179 (1999).
Cubizolles et al., “pEg7, A New Xenopus Protein Required For Mitotic Chromosome Condensation in Egg Extracts,”J. Cell Biol.143:1437-1446

Affiliated with

Also associated with

Rating

Transgenic animals and uses thereof does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Transgenic animals and uses thereof, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Transgenic animals and uses thereof will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-3990733