Multicellular living organisms and unmodified parts thereof and – Nonhuman animal
Patent
1994-12-29
1999-01-12
Low, Christopher S. F.
Multicellular living organisms and unmodified parts thereof and
Nonhuman animal
4351721, 4351723, 4352402, 4353201, 800DIG1, 935 6, 935 14, 935 22, 935 33, 935 70, C12N 506, A01K 67027
Patent
active
058593080
ABSTRACT:
A transgenic animal, the genome of which comprises a transgene for superoxide dismutase (SOD), erythrocyte-glutathione peroxidase (GPE), or plasma-glutathione peroxidase (GPP), is disclosed. A double transgenic animal comprising the transgenes for both SOD and GPE is also disclosed. Methods for making the transgenic animals are disclosed. Both the SOD gene and the two GP genes code for proteins which control the level of reactive oxidative species (ROS) which accumulate in cells as a result of metabolism. Cell lines from both SOD and GP transgenic animals and methods for use of the transgenic animals as models are also disclosed.
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Inouye Masayori
Mirochnitchenko Oleg
Low Christopher S. F.
University of Medicine And Denistry Of New Jersey
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