Transgenic animal with monocyte chemotactic protein 1 promoter

Multicellular living organisms and unmodified parts thereof and – Nonhuman animal – Transgenic nonhuman animal

Reexamination Certificate

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C800S003000, C536S023100

Reexamination Certificate

active

08076531

ABSTRACT:
The present invention relates to a transgenic animal, which comprises in its genome a recombinant polynucleotide encoding one or more reporter proteins and a monocyte chemotactic protein-1 (MCP-1) promoter, wherein the one or more reporter proteins are expressed under the control of the MCP-1 promoter. A method for monitoring endogenous expression of MCP-1 in vivo is also provided, which is useful for identifying a regulator of the expression of MCP-1 or an anti-inflammatory agent.

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Boekhoudt et al. Communication between NF-kB and Sp1 controls histone acetylation within the proximal promoter of the monocyte chemoattractant protein 1 gene. J. Immunology 170:4139-4147, 2003.
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Rajasekaran, et al., “Detection of Experimentally Induced Pulmonary Granuloma Inflammation in Monocyte Chemoattractant Protein-lReporter Mice”, Mol Imaging Biol (2009) D01: 10.1007/s11307-009-0261-9.
Tsuchiyama, et al., “Enhanced antitumor effects of a bicistronic adenovirus vector expressing both herpes simplex virus thymidine kinase and monocyte chemoattractant protein-1 against hepatocellular carcinoma”, Cancer Gene Therapy (2003) 10, 260-269.

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