Multicellular living organisms and unmodified parts thereof and – Nonhuman animal – Transgenic nonhuman animal
Reexamination Certificate
2009-11-25
2011-12-13
Nguyen, Quang (Department: 1633)
Multicellular living organisms and unmodified parts thereof and
Nonhuman animal
Transgenic nonhuman animal
C800S003000, C536S023100
Reexamination Certificate
active
08076531
ABSTRACT:
The present invention relates to a transgenic animal, which comprises in its genome a recombinant polynucleotide encoding one or more reporter proteins and a monocyte chemotactic protein-1 (MCP-1) promoter, wherein the one or more reporter proteins are expressed under the control of the MCP-1 promoter. A method for monitoring endogenous expression of MCP-1 in vivo is also provided, which is useful for identifying a regulator of the expression of MCP-1 or an anti-inflammatory agent.
REFERENCES:
patent: 5817911 (1998-10-01), Williams et al.
patent: 6217847 (2001-04-01), Contag
patent: 7595430 (2009-09-01), Jayakrishna
patent: 2006/0277613 (2006-12-01), Gambhir et al.
Boekhoudt et al. Communication between NF-kB and Sp1 controls histone acetylation within the proximal promoter of the monocyte chemoattractant protein 1 gene. J. Immunology 170:4139-4147, 2003.
Desai et al. Nitric oxide modulates MCP-1 expression in endothelial cells: Implications for the pathogenesis of pulmonary granulmatous vasculitis. Inflammation 27:213-223, 2003.
Carlsen, et al., “In Vivo Imaging of NF-kB Activity1” , The Journal of Immunology, 2002, 168:1441-1446.
Rajasekaran, et al., “Detection of Experimentally Induced Pulmonary Granuloma Inflammation in Monocyte Chemoattractant Protein-lReporter Mice”, Mol Imaging Biol (2009) D01: 10.1007/s11307-009-0261-9.
Tsuchiyama, et al., “Enhanced antitumor effects of a bicistronic adenovirus vector expressing both herpes simplex virus thymidine kinase and monocyte chemoattractant protein-1 against hepatocellular carcinoma”, Cancer Gene Therapy (2003) 10, 260-269.
National Health Research Institutes
Nguyen Quang
Occhiuti Rohlicek & Tsao LLP
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