Multicellular living organisms and unmodified parts thereof and – Nonhuman animal – Transgenic nonhuman animal
Reexamination Certificate
2003-02-27
2008-11-18
Wilson, Michael C. (Department: 1632)
Multicellular living organisms and unmodified parts thereof and
Nonhuman animal
Transgenic nonhuman animal
C800S003000, C800S018000, C800S021000
Reexamination Certificate
active
07453021
ABSTRACT:
The present invention provides animal model systems for cartilage-degenerative disease, which comprise transgenic animals which can express recombinant matrix-degrading enzymes (MDEs), particularly matrix metalloproteinases (MMPs), in a temporally and spatially regulated manner. The invention also provides methods for producing phenotypic indicators of cartilage-degenerative disease in a mammal and methods for determining the potential of a composition to counteract cartilage-degenerative disease. The invention also provides isolated nucleic acids encoding proMMP polypeptides that exhibit constitutive enzymatic activity and isolated proMMP polypeptides.
REFERENCES:
patent: 5625124 (1997-04-01), Falk et al.
patent: 5650298 (1997-07-01), Bujard et al.
patent: 5880327 (1999-03-01), Lubon et al.
patent: 5917123 (1999-06-01), McTiernan et al.
patent: 6028245 (2000-02-01), Wasylyk et al.
patent: WO95/32285 (1995-11-01), None
Pirok (J. Biol. Chem., 1997, vol. 272, p. 11566-11574).
Lefebvre (EMBO, May 1998, vol. 17, No. 19, p. 5718-5733).
Wall (1996, Theriogenology, vol. 45, p. 57-68).
Ebert (1988, Mol. Endocrinology, vol. 2, p. 277-283).
Niemann (Jan. 1998, Transgenic Research, vol. 7, p. 73-75).
Mullins (1990, Nature, vol. 344, p. 541-544).
Hammer (1990, Cell, vol. 63, p. 1099-1112).
Howland (PNAS, Feb. 5, 2002, vol. 99, No. 3, p. 1604-1609).
Mullins (1989, EMBO, vol. 8, p. 4065-4072).
Taurog (1988, J. Immunol., vol. 141, p. 4020-4023).
Liu, J. Cell Biol., 1995, vol. 130, p. 227-237.
Witty (Mol. Biol. of the Cell, Oct. 1995, vol. 6, p. 1287-1303).
D'Armiento (Mol. Cell. Biol., 1995, vol. 15, No. 10, p. 5732-5739).
Freije (J. Biol. Chem., Jun. 17, 1994, vol. 269, No. 24, p. 16766-16773).
Khokha (Cancer and Metastasis Reviews, 1995, vol. 14, p. 97-111).
MGI webpage description for MMP1a.
MGI webpage description for MMP1b.
MGI webpage description for MMP8.
NCBI description of XP—001072423.
NCBI description of NM—022221.
Allgood, Victoria E., and Eastman, E.M. ,“Chimeric Receptors as Gene Switches”,Current Opinion in Biotechnology, 8: pp. 474-479, 1997.
Billinghurst, R. Clark, et al.,“Enhanced Cleavage of Type II Collagen by Collagenases in Osteoarthritic Articular Cartilage”,J. Clin. Invest., 99(7):1534-1545, Apr. 1997.
Bradley, Allan, and Liu, P., “Target Practice in Transgenics”,Nature Genetics, 14:121-123, Oct. 1996.
Burcin, Mark M., et al., “Adenovirus-Mediated Regulable Target Gene Expression in vivo”,Proc. Natl. Acad. Sci. USA, 96:335-360, Jan. 1999.
D'Armiento, Jeanine, et al., “Collagenase Expression in the Lungs of Transgenic Mice Causes Pulmonary Emphysema”,Cell, 71: 995-961, Dec. 11, 1992.
D'Armiento, Jeanine, et al., “Collagenase Expression in Transgenic Mouse Skin Causes . . . Tumorigenesis”,Molecular and Cellular Biology, 15(15):5732-5739, Oct. 1995.
Ebert, Karl M. et al., “A Moloney MLV-Rat Somatotropin Fusion Gene Produces Biologically Active Somatotropin in a Transgenic Pig”,Molecular Endocrinology, pp. 277-282, 1988.
Feh., R., et al., “Ligand-Activated Site-Specific Recombination in Mice”,Proc. Natl. Acad. Sci. USA, 93:10887-19890, Oct. 1996.
Freije, Jose M.P., et al., “Molecular Cloning and Expression of Collagenase-3, a Novel Human Matrix Metalloproteinase Produced by Breast Carcinomas”,The Journal of Biological Chemistry, 269(24):16766-16773, Jun. 17, 1994.
Gordon, Jon W., “Transgenic Animals”,International Review of Cytology, 155:171-229, 1989.
Gossen, Manfred, and Bujard, H., “Tight Control of Gene Expression in Mammalian . . . Promoters”,Proc. Natl. Acad. Sci. USA, 89:5547-5551, Jun. 1992.
Gossen, Manfred, et al., “Transcriptional Activation by Tetracyclines in Mammalian Cells”,Science, 268:1766-1769, Jun. 23, 1995.
Hammer, Robert E., et al., “Spontaneous Inflammatory Disease in Transgenic Rats Expressing HLA-B27 . . . Human Disorders”,Cell, 63:1099-1112, Nov. 30, 1990.
Jaenisch, Rudolf, “Transgenic Animals”,Science, 240:1468-1474, Jun. 10, 1998.
Khoka, Rama, et al., “Utilization of Transgenic Mice in the Study . . . Inhibitors”,Cancer and Metastasis Reviews, 14:97-111, 1995.
Kistner, Andreas, et al., “Doxycycline-Mediated Quantitative . . . Transgenic Mice”,Proc. Natl. Acad. Sci. USA, 93:10933-10938, Oct. 1996.
Knauper, Vera, et al., “The Role of the C-Terminal Domain . . . Interaction”,The Journal of Biological Chemistry, 272(12): 7608-7616, 1997.
Knauper, Vera, et al., “Biochemical Characterization of Human Collagenase-3”,The Journal of Biological Chemistry, 271(3):1544-1550, Jan. 19, 1996.
Knight, C. Graham, et al., “A Novel Coumarin-Labelled Peptide . . . Metalloproteinases”,Federation of European Biochemical Societies, 296(3):263-266, Jan. 1992.
Kozaci, L. Didem, et al., “Degradation of Type II Collagen, . . . Cultures”,Arthritis&Rheumatism, 40(1):164-174, Jan. 1997.
Liu, Xin, et al., “A Targeted Mutation at the Known . . . Remodeling”,The Journal of Cell Biology, 130(1):227-237, Jul. 1995.
Mattioni, Tiziana, et al., “Regulation of Protein Activities by Fusion to Steroid Binding Domains”,Methods in Cell Biology, 43:335-352, 1994.
Mitchell, Peter G., et al., “Cloning, Expression, . . . Osteoarthritic Cartilage”,J. Clin. Invest., 97(3):761-768, Feb. 1996.
Mullins, Linda J., and Mullins, John J., “Perspectives Series: Molecular Medicine in Genetically Engineered Animals”,J. Clin. Invest., 98(11):S37-S40, 1996.
Mullins, J.J., et al., “Fulminant Hypertension . . . Ren-2 Gene”,Nature, 344:541-544, Apr. 5, 1990.
Mullins, J.J., et al., “Expression of the DBA/2J Ren-2 . . . Transgenic Mice”,The EMBO Journal, 8(13):4065-4072, 1989.
No, David, et al., “Ecdysone-Inducible Gene Expression in Mammalian Cells and Transgenic Mice”,Proc. Natl. Acad. Sci. USA, 93:3346-3351, Apr. 1996.
Overbeek, Paul A., “Transgenic Phenomenology”,Transgenic Animal Technology, pp. 96-98.
Robl, James, M.,and Heideman, J.K., “Production of Transgenic Rats and Rabbits”,Transgenic Animal Technology, pp. 265-270, 1994.
Rossant, J., “Manipulating The Mouse Genome: Implications for Neurobiology”,Neuron, 2:323-334, Mar. 1990.
Sanchez-Lopez, Rosana, et al., “Structure-Function Relationships in the Collagenase Family Member Transin”,The Journal of Biological Chemistry, 263(24):11892-11900, Aug. 1992.
Shapiro, Steven, D., “Mighty Mice: Transgenic Technology ‘Knocks out’ Questions of Matrix Metalloproteinase”,Matrix Biology, 15:527-533, 1997.
Shockett, Penney E., and Schatz, D.G., “Diverse Strategies for Tetracycline-Regulated Inducible Gene Expression”,Proc. Natl. Acad. Sci. USA, 93:5173-5176, May 1996.
Shockett, Penney, and Schatz, D.G., “Switching on Gene Expression”,Nature Biotechnology, vol. 15., Mar. 1997.
Sympson, Carolyn J., et al., “Targeted Expression of Stromelysin-1 . . . Gene Expression”,The Journal of Cell Biology, 125(3):681-693, May 1994.
Taurog, Joel, D., et al., “HLA-B27 in Inbred and Non-Inbred Transgenic Mice”,The Journal of Immunology, 141(11):4020-4023, Dec. 1, 1988.
Wall, R.J., “Transgenic Livestock: Progress and Prospects for the Future”,Theriogenology, 45:57-68, 1996.
Wang, Yaolin, et al., “Ligand-Inducible and Liver-Specific Target Gene Expression in Transgenic Mice”,Nature Biotechnology, 15:239-243, Mar. 1997.
Wang, Yaolin, et al., “A Regulatory System for Use in Gene Transfer”,Proc. Natl. Acad. Sci. USA, 91:8180-8184, Aug. 1994.
Wang, Y., et al., “Positive and Negative Regulation of Gene Expression in Eukaryotic Cells with an Inducible Transcriptional Regulator”,Gene Therapy, 4:432-441, 1997.
Watson, James, D., et al., “The Introduction of Foreign Genes into Mice”,Recombinant DNA
Killar Loran Marie
Neuhold Lisa Ann
Fitzpatrick, Cella, Harper and Scinto
Wilson Michael C.
Wyeth
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