Drug – bio-affecting and body treating compositions – In vivo diagnosis or in vivo testing – Testing efficacy or toxicity of a compound or composition
Patent
1994-02-17
1998-02-17
Campell, Bruce R.
Drug, bio-affecting and body treating compositions
In vivo diagnosis or in vivo testing
Testing efficacy or toxicity of a compound or composition
4351723, 800 2, 800DIG1, 514 2, A61K 4900
Patent
active
057188831
ABSTRACT:
A transgenic animal, whose germ cells and somatic cells contain a transgene including a DNA sequence encoding a CD28 ligand and a tissue-specific promoter operably linked to the DNA sequence, wherein the tissue-specific promoter effects expression of the CD28 ligand in cells of a specific tissue of the animal is disclosed. This animal serves as a transgenic model for specific autoimmune diseases.
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Harlan David M.
June Carl H.
Campell Bruce R.
Mandragouras Amy E.
Spevack A. David
The United States of America as represented by the Secretary of
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