Chemistry: molecular biology and microbiology – Micro-organism – per se ; compositions thereof; proces of... – Bacteria or actinomycetales; media therefor
Patent
1997-03-06
2000-02-15
Sisson, Bradley
Chemistry: molecular biology and microbiology
Micro-organism, per se ; compositions thereof; proces of...
Bacteria or actinomycetales; media therefor
4353201, 435 691, 435197, 536 231, 536 235, 536 232, 536 241, C12N 121
Patent
active
060251832
ABSTRACT:
The present invention provides a transgenic animal assay system which provides a model system for testing for, and treatment of, cholinergic deficits and imbalances in mammals such as cognitive functioning in Alzheimer's patients, certain types of retinal photoreceptor degeneration, hematopoietic disorders, and screening for and susceptibility to anti-cholinesterase compounds. The transgenic animals and progeny thereof are transformed with a recombinant expression vector of the present invention. The recombinant expression vector comprises a DNA sequence encoding a heterologous cholinesterase (ChE) enzyme and promoter.
REFERENCES:
patent: 4736866 (1988-04-01), Leder et al.
patent: 5175383 (1992-12-01), Leder et al.
patent: 5175384 (1992-12-01), Krimpenfort et al.
patent: 5175385 (1992-12-01), Wagner et al.
patent: 5221778 (1993-06-01), Byrne et al.
patent: 5288846 (1994-02-01), Quertermous et al.
patent: 5298422 (1994-03-01), Schwartz et al.
patent: 5347075 (1994-09-01), Sorge
patent: 5360735 (1994-11-01), Weinshank et al.
patent: 5387742 (1995-02-01), Cordell
patent: 5464764 (1995-11-01), Capecchi et al.
patent: 5487992 (1996-01-01), Capecchi et al.
patent: 5595903 (1997-01-01), Soreq et al.
Li et al. (1991) "Gene Structure of Mammalian Acetylcholinesterase" J. Bi Chem. 266/34:23083-90, 1991.
Getman et al. (1992) "The Human Gene Encoding Acetylcholinesterase is Located on the Long Arm of Chromosome 7" Am. J. Hum. Genet. 51:170-177, 1992.
Aigner et al. (1995) "Overexpression of the neural growth-associated protein GAP-43 induces nerve sprouting in the adult nervous system of transgenic mice" Cell 83:269-278.
Aizenman, E. (1988) Science 239:1293-1296.
Andres et al. (1996) "Transgenic ACHE induces neuromuscular deterioration in mice" Submitted for publication.
Andrews (1988) "Human teratocarcinomas" Biochim. Biophys. Acta 948:17-36.
Anglister and McMahan (1985) "Basal lamina directs acetylcholinesterase accumulation at synaptic sites in regenerating muscle" J. Cell Biol. 101:735-743.
Anglister et al. (1994) "Acetylcholinesterase density and turnover number at frog neuromuscular junctions, with modeling of their role in synaptic function" Neuron 12:783-794.
Ariel and Daw (1982a) J. Physiol. 324:135-160.
Ariel and Daw (1982b) J. Physiol. 324:161-186.
Auld et al. (1995) "Glioactin, a novel transmembrane protein on peripheral glia is required to form blood-brain barrier in Drosophila" Cell 81:757-767.
Baldessarini (1990) Drugs and the treatment of psychiatric disorders. In: Pharmacological Basis of Therapeutics, pp. 383-435, Gilman, Rall, Nies, and Taylor (eds) Pergamon Press, New York.
Beeri et al. (1994) "Testicular amplification and impaired transmission of human butyricholinesterase cDNA in transgenic mice" Human Reprod., 9:284-292.
Beeri et al. (1995) "Transgenic expression of human acetylcholinesterase induces progressive cognitive deterioration in mice" Current Biology, 5:1063-1071.
Bickel, et al. (1993) "Pharmacologic effects in vivo in brain by vector-mediated peptide drug delivery" Proc. Natl. Acad. Sci. USA 90(7):2618-2622.
Bierer et al. (1995) J. Neurochem. 64:749-760.
Blackwell et al. (1990) "Sequence-specific DNA binding by the c-Myc protein" Science 250:1149-1152.
Bourtchuladze et al. (1994) "Deficient long-term memory in mice with a targeted mutation of the cAMP-responsive element-binding protein" Cell 79:59-68.
Brem et al. (1993) "Polymers as controlled drug delivery devised for the treatment of malignant brain tumors" Eur. J. Pharm. Biopharm. 39:2-7.
Burke and Olson (1991). "Preparation of Clone Libraries in Yeast Artificial-Chromosome Vectors" in Methods in Enzymology, vol. 194, "Guide to Yeast Genetics and Molecular Biology", eds. C. Guthrie and G. Fink, Academic Press, Inc., Chap. 17, pp. 251-270.
Capecchi (1989), "Altering the genome by homologous recombination" Science, 244:1288-1292.
Connell et al. (1991) Proc. Natl. Acad. Sci. USA 88:723-726.
Conquet et al. (1994) "Motor deficit and impairment of synaptic plasticity in mice lacking mGluRl" Nature 372:237-243.
Dan and Poo, "Retrograde interactions during formation and elkination of neuromuscular synapes" Curr. Opin. in Neurobiol. 4:95-100.
Darboux et al. (1996) The structure-function relationships in Drosophila neurotactic show that cholinesterasic domains may have adhesive properties EMBO J. 15:4835-4843.
Davies et al. (1992). "Targeted alterations in yeast artificial chromosomes for inter-species gene transfer", Nucleic Acids Research, 20(11):2693-2698.
De La Escalera et al. (1990) "Characterization and gene cloning of neurotactin, a Drosophila transmembrane protein related to cholinesterases" EMBO J. 9:3593-3601.
Dickinson et al. (1993). "High frequency gene targeting using insertional vectors", Human Nolecular Genetics, 2:1299-1302.
Dretchen et al. (1992) "Protection against cocaine toxicity by human butyrylcholinesterase (BCHE) in rat" (abstract) FASEB J. 6:A1282.
Drews (1975) "Cholinesterase in embryonic development" Prog. Histochem. Cytochem 7:1-52.
Duval, et al. (1992) "H and T subunits of acetylcholinesterase from Torpedo, expressed in COS cells, generate all types of molecular forms" J. Cell Biol. 118:641-653.
Eaton and Lambert (1957) "Electromyography and electric stimulation of nerves in diseases of motor unit: observation on the myasthenic syndrome associated with malignant tumors" JAMA 163:1117-1124.
Eckstein (1985) "Nucleotide phosporothioates" Ann. Rev. Biochem. 54:367-402.
Ehrlich et al. (1992) Genomics 13:1192-1197.
Ehrlich et al. (1994) "Population diversity and distinct haplotype frequencies associated with ACHE and BCHE genes of Israeli Jews from Trans-Caucasion Georgia and from Europe" Genomics 22:288-295.
Engel and Santa (1971) "Histometric analysis of the ulastructure of the neuromuscular junction in myasthenia gravis and in the myasthenic syndrome" Ann. N.Y. Acad. Sci. 183:46-63.
Fitzpatrick-McElligot and Stent (1981) "Appearance and localization of acetylcholinesterase in embryo of the leech Helodbella Triserialis" J. Neurosci. 1:901-907.
Freeman, J.A. (1977) Nature 269:218-222.
Fuentes and Taylor (1993) "Control of acetylcholinesterase gene expression during myogensis" Neuron 10:679-687.
Garcia-Coluna and Miledi (1995) "Effects of serotonergic agents on neuronal nicotinic acetylcholine receptors" Proc. Natl. Acad. Sci. USA 92:2919-2923.
Gatley (1991) "Activities of the enantiomers of cocaine and some related compounds as substrates and inhibitors of plasma butyrylcholinesterase" Biochem. Pharmacol. 41:1249-1254.
Gavrieli et al. (1992) J. Cell Biol. 119:493-501.
Gibney and Taylor (1990) "Biosynthesis of Torpedo acetylcholinesterase in mammalian cells" J. Biol. Chem. 265:12576-12583.
Grant et al. (1992) "Impaired long-term potentiation, spatial learning, and hipocampal development in fyn mutant mice" Science 258:1903-1909.
Greenberg et al. (1988) "Characterization of a new megakaryocytic cell line--the DAMI cell" Blood 72:1968-1977.
Greensmith and Vrbova (1991) "Neuromuscular contacts in the developing rat solleus depend on muscle activity" Dev. Brain Res. 62:121-129. [*n/a--will mail in].
Hall (1995) "Laminin b2 (S-Laminin): A new player at the synapse"Science 269:362-363.
Han et al. (1991) "Induction of formation of presynaptic terminals in neuroblastoma cells by synapsin IIb" Nature 349:697-700.
Hietanen et al. (1990) "Immunocytochemical study of the relations of acetylcholinesterase, enkephalin-, substance P-, choline acetyltransferase- and calcitonin gene-related peptide-immunoreactive structures in the ventral horn of rat spinal cord" Histochem. 93:473-477.
Humphries et al. (1992) Science 256:804-808.
Hutchins, J.B. (1987) Exp. Eye Res. 45:1-38.
Huxley et al. (1991). "The human HPRT gene on a yeast artificial chromosome is functional when transferred to mouse cells by cell fusion", Genomics, 9:742-750.
Ichtchenko et al. (1995) "Neuroligin 1: a splice site-specific ligand for beta-neurexins" Cell 81:435-443.
Ip et al. (1994) "Neurogenic expression of snail is controlled by separable CNS and PNS promoter elements" Development 120:199-207.
Isenschmid, et al. (1989) "A comprehensiv
Shani Moshe
Soreq Hermona
Zakut Haim
Longton Enrique D.
Sisson Bradley
Yissum Research Development Company of the Hebrew University of
LandOfFree
Transgenic animal assay system for anti-cholinesterase substance does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Transgenic animal assay system for anti-cholinesterase substance, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Transgenic animal assay system for anti-cholinesterase substance will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1905012