Transgenic amorpha-4, 11-diene synthesis

Details Transgenic amorpha-4, 11-diene synthesis Transgenic amorpha-4, 11-diene synthesis

2006-07-18

2009-06-02

Saidha, Tekchand (Department: 1652)

Chemistry: molecular biology and microbiology

Enzyme , proenzyme; compositions thereof; process for...

Lyase

C435S252300, C435S320100, C536S023200

Reexamination Certificate

active

07541172

ABSTRACT:
The present invention relates to an isolated DNA sequence encoding a polypeptide having the biological activity of amorpha-4,11-diene synthase. This DNA sequence can be used for the transformation of bacteria, yeasts and plants for the production of amorpha-4,11-diene, a specific precursor in the synthesis of artemisinin, in the respective organisms. The invention also relates to these organisms.

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Preliminary Amendment filed Feb. 26, 2001, in U.S. Appl. No. 09/763,822, now U.S. Patent 7,091,027.
Sequence Amendment filed Jul. 29, 2002, in U.S. Appl. No. 09/763,822, now U.S. Patent 7,091,027.
Response to Notification of Defective Response and Sequence Amendment filed May 5, 2003, in U.S. Appl. No. 09/763,822, now U.S. Patent 7,091,027.
Restriction Requirement mailed Apr. 22, 2004, in U.S. Appl. No. 09/763,822, now U.S. Patent 7,091,027.
Election with Traverse filed May 25, 2004, in U.S. Appl. No. 09/763,822, now U.S. Patent 7,091,027.
Non-Final Office Action mailed Jun. 18, 2004, in U.S. Appl. No. 09/763,822, now U.S. Patent 7,091,027.
Amendment filed Sep. 20, 2004, in U.S. Appl. No. 09/763,822, now U.S. Patent 7,091,027.
Non-Final Office Action mailed Dec. 1, 2004, in U.S. Appl. No. 09/763,822, now U.S. Patent 7,091,027.
Amendment filed Jun. 1, 2005, in U.S. Appl. No. 09/763,822, now U.S. Patent 7,091,027.
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Notice of Allowance and Fee(s) due mailed Mar. 24, 2006, in U.S. Appl. No. 09/763,822, now U.S. Patent 7,091,027.

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