Transgenic algae for delivering antigens to an animal

Details Transgenic algae for delivering antigens to an animal Transgenic algae for delivering antigens to an animal

2001-06-20

2008-08-12

Kaushal, Sumesh (Department: 1633)

Drug, bio-affecting and body treating compositions

Whole live micro-organism, cell, or virus containing

Genetically modified micro-organism, cell, or virus

C424S093100, C424S184100, C435S069100, C435S320100, C435S410000, C435S468000

Reexamination Certificate

active

07410637

ABSTRACT:
Delivery systems and methods are provided for delivering a biologically active protein to a host animal. The systems and methods provided include obtaining an algal cell transformed by an expression vector, the expression vector comprising a nucleotide sequence coding for the biologically active protein, operably linked to a promoter. In one illustrated embodiment, the biologically active protein is an antigenic epitope and upon administration to the animal the algal cell induces an immune response in the host animal.

REFERENCES:
patent: 5484719 (1996-01-01), Lam et al.
patent: 5654184 (1997-08-01), Curtiss, III et al.
patent: 5661017 (1997-08-01), Dunahay et al.
patent: 5670349 (1997-09-01), Cramer et al.
patent: 5679880 (1997-10-01), Curtiss, III et al.
patent: 5686079 (1997-11-01), Curtiss, III et al.
patent: 5804408 (1998-09-01), Hagiwara et al.
patent: 5821087 (1998-10-01), Lowe et al.
patent: 5914123 (1999-06-01), Arntzen et al.
patent: 5958422 (1999-09-01), Lomonossoff
patent: 6034298 (2000-03-01), Lam et al.
patent: 6136320 (2000-10-01), Arntzen et al.
patent: 6444805 (2002-09-01), Sohn et al.
patent: 2003/0022359 (2003-01-01), Sayre et al.
patent: 0108580 (1984-05-01), None
patent: 0342824 (1989-11-01), None
patent: 0342824 (1989-11-01), None
patent: 0773295 (1997-05-01), None
patent: 0971034 (2000-01-01), None
patent: 1114867 (2001-07-01), None
patent: WO 96/11707 (1996-04-01), None
patent: WO 97/39106 (1997-10-01), None
patent: WO 99/60838 (1999-12-01), None
patent: 00/73455 (2000-12-01), None
patent: 01/98335 (2001-12-01), None
Muiswinkel et al Aquaculture, 172:103-110, 1999.
Scapigliati et al. Dev Comp Immuno 26:151-60, 2002.
Hilleman Vaccine, 2:651-665, 2002.
Eibl et al, The Plant Journal 19(3):333-345, 1999.
Chen et al, Plant Physiol. 114:265-273, 1997.
Ishikura et al, J Biosci Bioeng. 87(3):307-314, 1999.
Davies et al., “Sequences controlling transcription of theChlamydomonas reinhardtiiβ2-tubulin gene after deflagellation and during the cell cycle.”, (Abstract Only),Mol. Cell. Bio., 14(8), pp. 5164-5174, (1994).
Davies et al., “Expression of the arylsulfatase gene from the β2-tubulin promoter inChlamydomonas reinhardtii”, Nucleic Acids Research, vol. 20, No. 12, pp. 2959-2965, (1992).
Gorman et al., “Cytochrome F and Plastocyanin: Their Sequence in the Photosynthetic Electron Transport Chain ofChlamydomonas reinhardi”,P.N.A.S., vol. 54, pp. 1665-1669, (1965).
Debuchy et al., “The argininosuccinate lyase gene ofChlamydomonas reinhardtii: an important tool for nuclear transformation and for correlating the genetic and molecular maps of the ARG7 locus”,EMBO Journal, 8: pp. 2803-2809, (1989).
Daniel I. Arnon, “Copper Enzymes in Isolated Chloroplasts. Polyphenoloxidase inBeta vulgaris”, Plant Physiology, vol. 24, No. 1, pp. 1-15, (Jan. 1949).
Hutchinson et al., “Chloroplast transformation”,Molecular Genetics of Photosynthesis, Chapter 9, pp. 181-196, (1996).
Ruffle et al., “Functional Analysis of Photosystem II”,The Molecular Biology of Cholorplasts and Mitochondria in Chlamydomonas,, Chapter 16, pp. 287-322, (1998).
D'Souza et al., “Effects of monospecific and mixed-algae diets on survival, development and fatty acid composition of penaeid prawn (Penaeusspp.) larvae”,Marine Biology, 133:pp. 621-633, (1999).
Alabi, et al., “The efficacy of immersion as opposed to oral vaccination ofPenaeus indicuslarvae againstVibrio harveyi”, Aquaculture, vol. 178, pp. 1-11, (1999).
Tsai et al., “Growth Enhancement of Juvenile Striped Mullet by Feeding Recombinant Yeasts Containing Fish Growth Hormone”,The Progressive Fish Culturist, vol. 56, pp. 7-12, (1994).
Haq et al., “Oral Immunization with a Recombinant Bacterial Antigen Produced in Transgenic Plants”,Science, vol. 268, pp. 714-716, (1995).
Mason et al., “Transgenic plants as vaccine production systems”,Tibtech, vol. 13, pp. 388-392, (1995).
Mason et al., “Expression of hepatitis B surface antigen in transgenic plants”,Proc. Natl. Acad. Sci., vol. 89, pp. 11745-11749, (1992).
Moffat, “Exploring Transgenic Plants As a New Vaccine Source”,Science, vol. 268, (1995).
Gudding, et al., “Recent developments in fish vaccinology”,Veterinary Immunology and Immunopathology, 72, pp. 203-212, (1999).
Burow et al., “Isolation of cDNA clones of genes induced upon transfer ofChlamydomonas reinhartiicells to low CO2,”Plant Molecular Biology, 31(2): 443-448 (1996).
O'Farrell et al., “Differential expression of the virulence-associated protein p57 and characterization of its duplicated gene msa in virulent and attenuated strains ofRenibacterium salmoninarum,” Diseases of Aquatic Organisms, 38(2): 115-123 (1999).
Piganelli et al., “Evaluation of a whole cell, p57- vaccine againstRenibacterium salmoninarum,” Diseases of Aquatic Organisms, 36(1): 37-44 (1999).
Wiens et al., “Antigenic and functional characterization of p57 produced byRenibacterium salmoninarum,” Diseases of Aquatic Organisms, 37(1): 43-52 (1999).
Hilleman, M. R. “Current Overview of the Pathogenesis and Prophylaxis of Measles with Focus on Practical Implications” (2002) Vaccine vol. 20, pp. 651-665.
Van Muiswinkel, V. B. et al. “The influence of Environmental and Genetic Factors on the Disease Resistance of Fish” (1999) Aquaculture vol. 172, pp. 103-110.
Scapigliati, G. et al. “The Immune System of Sea Bass, Dicentrarchus Labrax, Reared in Aquaculture” (2002) Dev Comp Immuno vol. 26, pp. 151-160.
Eibl, C. et al. “In Vivo Analysis of Plastid psbA, rbcL and rpl32 UTR Elements by Chloroplast Transformation: Tobacco Plastid Gene Expression is Controlled by Modulation of Transcript Levels and Translation Efficiency” (1999) The Plant Journal vol. 19(3), pp. 333-345.
Chen, Z. et al. “Cloning and Overexpression of Two cDNAs Encoding the Low-CO2-Inducible Chloroplast Envelope Protein LIP-36 fromChlamydomonas reinhardtii” (1997) Plant Physiol. vol. 114, pp. 265-273.
Blowers, A. et al. “Transcriptional Analysis of Endogenous and Foreign Genes in Chloroplast Transformants ofChlamydomonas” (1990) The Plant Cell, vol. 2, pp. 1059-1070.
Blowers, A. et al. “Studies onChlamydomonasChloroplast Transformation: Foreign DNA Can Be Stably Maintained in the Chromosome” (1989) The Plant Cell, vol. 1. pp. 123-132.
pSSCR7 A Transformation Vector for Expression of Foreign Genes in the Nuclear Genome ofChlamydomonas reinhardtii, S. Siripornadulsil and R. Sayre, poster, presented at the Northeast Algal Society Meeting, Apr. 17, 1999.

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