Transforming growth factor beta (TGF-β) blocking...

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Carbohydrate doai

Reexamination Certificate

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C435S325000, C435S377000, C435S375000, C536S023100, C536S024100, C536S024500

Reexamination Certificate

active

06841542

ABSTRACT:
The invention relates to TGF-β blocking agent-treated HSC compositions and methods comprising the same. The TGF-β blocking agent-treated stem cells are viable for an extended time in culture without replication or differentiation and upon transfer to appropriate conditions are capable of long term hematopoietic reconstitution.

REFERENCES:
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patent: 5958774 (1999-09-01), Klein et al.
Written Opinion mailed Oct. 30, 2002, from IPA/US, Commissioner of Patents and Trademarks, for Int'l. application No. PCT/US01/21420; Int'l. Filing Date: Jul. 6, 2001.
Batard, P., et al., “TGF-β1 maintains hematopoietic immaturity by a reversible negative control of cell cycle and induces CD34 antigen up-modulation,”Journal of Cell Science,113:383-390 (2000).
Fortunel, N., et al., “Transforming growth factor-β: pleiotropic role in the regulation of hematopoiesis,”Blood, 95:(6) 2022-2036 (2000).
Hatzfeld, J., et al., “Release of Early Human Hematopoietic Progenitors from Quiescence by Antisense Transforming Growth Factor β1 or Rb Oligonucleotides,”J. Exp. Med., 174:925-929 (1991).
Hudziak, R.M., et al., “Antiproliferative Effects of Steric Blocking Phosphorodiamidate Morpholino Antisense Agents Directed against c-myc,”Antisense and Nucleic Acid Drug Development, 10:163-176 (2000).
Hudziak, R.M., et al., “Resistance of Morpholino Phosphorodiamidate Oligomers to Enzymatic Degradation,”Antisense and Nucleic Acid Drug Development, 6:267-272 (1996).
Summerton, J., et al., “Morpholino Antisense Oligomers: Design, Preparation, and Properties,”Antisense and Nucleic Acid Drug Development, 7:187-195 (1997).

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