Transforming growth factor beta 1 (TGFβ1) haplotypes...

Details Transforming growth factor beta 1 (TGFβ1) haplotypes... Transforming growth factor beta 1 (TGFβ1) haplotypes...

2005-06-06

2010-12-28

Kapushoc, Stephen (Department: 1634)

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

C536S023500, C435S006120

Reexamination Certificate

active

07858763

ABSTRACT:
The present invention is related to the haplotypes of human Transforming Growth Factor Beta1 (TGFβ1) and prediction of susceptibility for immunological disorders. More particularly the present study is the first study in any population, identifying novel protective and risk haplotypes of the TGFβ1 gene The present invention also relates to allelic variants of the human Transforming Growth Factor Beta1 (TGFβ1) gene. The said invention also provides primers and methods suitable for the detection of these haplotypes and allelic variants for the prediction of an individual's disease susceptibility, and/or the genetic analysis of the TGFβ1 gene for immunological disorders, particularly asthma. A vital aspect of the present study provides a method for predicting susceptibility of individuals to immunological disorders, particularly asthma.

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