Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Recombinant dna technique included in method of making a...
Patent
1995-06-06
2000-06-13
Kemmerer, Elizabeth
Chemistry: molecular biology and microbiology
Micro-organism, tissue cell culture or enzyme using process...
Recombinant dna technique included in method of making a...
455325, 4552523, 4553201, 536 235, C12N 121, C12N 510, C12N 1512, C12N 1563
Patent
active
060748397
ABSTRACT:
The present invention discloses transforming growth factor alpha HII polypeptides and polynucleotides encoding such polypeptides. Also provided is a procedure for producing such polypeptides by recombinant techniques and therapeutic uses of the polypeptides which include stimulating wound healing, treating neurological disorders, treating ocular disorders, treating kidney and liver disorders and stimulating embryogenesis and angiogenesis. Also disclosed are antagonists against such polypeptide and their use as a therapeutic to treat neoplasia. Also disclosed are diagnostic assays for detecting altered levels of the polypeptide of the present invention and mutations in the nucleic acid sequences which encode the polypeptides of the present invention.
REFERENCES:
patent: 5115096 (1992-05-01), Shoyab et al.
patent: 5256643 (1993-10-01), Persico et al.
patent: 5633147 (1997-05-01), Meissner et al.
Mann, B. G., et al., Cell, 73:249-261 (1993).
Cook, P.W., et al., Cancer Research, 52:3224-3227 (1992).
Woo, D.D.L., et al., Protein Engineering, 3:29-37 (1989).
Prigent, S. A., et al., Progress in Growth Factor Research, 4:1-24 (1992).
Derynck, R., et al., Molecular Reproduction & Development, 27: 3-9 (1990).
Kudlow, J. E., et al., Cancer Biology, 1: 293-302 (1990).
Holmes, W. E., et al., Science, 256:1205-1210 (1992).
Schultz, G.D., et al., J. of Cellular Biochem., 45: 346-352 (1991).
Shing, et al., Science, 259: 1604-1607 (1993).
Sasada, et al., Biochemical & Biophysical Research Comm., 190:1173-1179 (1993).
Michikawa, et al., FEBS, 336:27-33 (1993).
George, et al., Macromolecular Sequencing & Synthesis, Schlesinger, Alan R. Liss, Inc. NY: pp. 127-149 (1988).
Nathan et al. J. Cell Biol. 113:981-986, 1991.
Peles et al. BioEssays 15(12), 815-824, 1993.
Eib et al. Genbank, Locus HSU19878, Human Transmembrane Protein mRNA, Accession No. U19878, 1995.
Holmes et al. Science 256, 1205-1210, 1992.
Adams Mark D.
Fei-Wei Ying
Fuldner Rebecca A.
Meissner Paul S.
Brookes A. Anders
Human Genome Sciences Inc.
Kemmerer Elizabeth
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