Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Recombinant dna technique included in method of making a...
Patent
1997-11-05
2000-07-04
Guzo, David
Chemistry: molecular biology and microbiology
Micro-organism, tissue cell culture or enzyme using process...
Recombinant dna technique included in method of making a...
4352523, 43525231, 4352525, 435471, 435477, 435485, C12P 2100, C12N 121
Patent
active
060837187
ABSTRACT:
Novel methods and novel industrial unicellular microorganism strains, particularly industrial Bacillus strains, are provided for enhanced production of endogenous and exogenous polypeptides. Cloning vehicles containing the gene expressing the polypeptide of interest are introduced into a compatible host. Transformed hosts harboring the introduced vehicle in a stable way by integration of the vehicle into the host cells chromosome are selected. Efficient transfer of the vehicle containing the gene of interest is achieved, with the resulting industrial strain transformants being effective, stable producers of the desired polypeptide product.
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Andreoli Peter Michael
Mulleners Leo J. S. M.
Sanders Johan Pieter Marinus
Van Den Berg Johannes Abel
Van Ee Jan Hendrik
Gist-brocades, N.V.
Guzo David
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