Transformed cell, method of screening anti-aging agent and...

Chemistry: molecular biology and microbiology – Animal cell – per se ; composition thereof; process of... – Rodent cell – per se

Reexamination Certificate

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

C435S357000, C435S366000, C435S364000

Reexamination Certificate

active

10484033

ABSTRACT:
This invention provides a novel transformed cell useful in constructing an anti-aging agent screening system, a screening method which uses the same and an anti-aging agent, and it relates to a transformed cell in which a gene coding for (a) a protein capable of phosphorylating p38 protein, or (b) p38 protein, a mutant of p38 protein, a kinase domain of p38 protein, a kinase domain of p38 protein mutant or a fusion protein containing them is transformed into a normal cell, a screening method which uses this transformed cell and an anti-aging agent which uses a compound obtained by the screening method as the active ingredient.

REFERENCES:
patent: 9-271395 (1997-10-01), None
patent: 97/44467 (1997-11-01), None
patent: WO 98/05761 (1998-02-01), None
patent: WO 98/14592 (1998-04-01), None
patent: 99/67283 (1999-12-01), None
patent: WO 00/00491 (2000-01-01), None
Moriguchi, T. et al., A Novel Kinase Cascade Mediated by Mitogen-activated protein Kinase Kinase 6 and MKK3, J. Biol. Chem. (1996), vol. 271, No. 23, pp. 13675 to 13679.
Raingeaud, J. et al., MKK3- and MKK6- Regulated Gene Expression Is Mediated by the p38 Mitogen-Activated Protein Kinase Signal Transduction Pathway, Mol. Cell. Biol. (1996), vol. 16, No. 3, pp. 1247 to 1255.
Suh, Y. et al., Differential activation of mitogen-activated protein kinases by methyl methanesulfonate in the kidney of young and old rates, Mutatioon Research, Oct. 18, 2001 vol. 497, No. 1/2, pp. 11 to 18.
Mutsuhiro Takekawa et al., “A human homolog of the yeast Ssk2/Ssk22 MAP kinase kinase kinases, MTK1, mediates stress-induced activation of the p38 and JNK pathways”, The EMBO Journal (1997) vol. 16, No. 16, pp. 4973-4982.
Igor Dozmorov et al., “Array-Based Expression Analysis of Mouse Liver Genes: Effect of Age and of the Longevity Mutant Prop1df” Journal of Gerontology (2001) vol. 56A, No. 2, pp. B72-B80.
Xuechu Zhen et al., “Age-Associated Impairment in Brain MAPK Signal Pathways and the Effect of Caloric Restriction in Fischer 344 Rats” Journal of Gerontology (1999) vol. 54A, No. 12, pp. B539-B548.
Zhi-Qiang Xiao et al. “Induction of transcriptional activity of AP-1 and NF-kB in the gastric mucosa during aging” Am J. Physiol Gastrointest Liver Physiol (2000) vol. 278, No. 6, pp. G855-G865.
Eamonn O'Donnell et al., “Age-related impairment in LTP is accompanied by enhanced activity of stress-activated protein kinases: analysis of underlying mechanisms” European Journal of Neuroscience (2000) vol. 12, No. 1, pp. 345-352.
Chen-Hsiung Yeh et al., “Requirement for p38 and p44/p42 Mitogen-Activated Protein Kinases in RAGE-Mediated Nuclear Factor-kB Transcriptional Activation and Cytokine Secretion” DIABETES (2001) vol. 50, No. 6, pp. 1495-1504.
Michael M. Awad et al., “Growth Regulation via p38 Mitogen-activated Protein Kinase in Developing Liver” The Journal of Biological Chemistry (2000) vol. 275, No. 49, pp. 38716-38721.
Jun-o Deguchi et al., “Angiotensin II Stimulates Platelet-Derived Growth Factor-B Chain Expression in Newborn Rat Vascular Smooth Muscle Cells and Neointimal Cells Through Ras, Extracellular Signal-Regulated Protein Kinase, and c-Jun N-Terminal Protein Kinase Mechanism” Circulation Research (1999) vol. 85, No. 7 pp. 565-574.
Supplementary Partial European Search Report dated Jan. 3, 2005.

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Transformed cell, method of screening anti-aging agent and... does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Transformed cell, method of screening anti-aging agent and..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Transformed cell, method of screening anti-aging agent and... will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-3884874

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.