Transformed cell lines producing human monoclonal antibodies spe

Details Transformed cell lines producing human monoclonal antibodies spe Transformed cell lines producing human monoclonal antibodies spe

1993-04-01

1996-05-28

Lacey, David L.

Chemistry: molecular biology and microbiology

Spore forming or isolating process

5303884, 53038815, C12N 510, C07K 1612, C07K 1618

Patent

active

055210856

ABSTRACT:
The present invention relates to human monoclonal antibodies capable of plurally binding with O-antigens of Pseudomonas aeruginosa, relates to novel parent cell lines for producing human hybridomas derived from human immunoglobulin synthesizing cells, which cell lines themselves incapable of producing human immunoglobulin and capable of fusing with human antibody-producing cells, relates to human-human hybridomas which can secrete monoclonal antibodies capable of binding with at least one of serotypes of Pseudomonas aeruginosa, relates to pharmaceutical compositions for prophylaxis or therapy of Pseudomonas aeruginosa infectious diseases, and relates to prophylactic or therapeutic methods for Pseudomonas aeruginosa infectious diseases.

REFERENCES:
patent: 4834975 (1989-05-01), Siadak et al.
patent: 5252480 (1993-10-01), Yokota et al.
Chemical Abstracts, 103, 1985, 69500a.
Chemical Abstracts, 104, 1986, 32782p.
Sawada, S. et al., J. Gen Microbiol, 133:3581-3590, 1987.
Verhoef, J. et al., Eur. J. Clin Microbiol Infect Dis, 9(4):247-250, Apr. 1990.
Cross, A. S. et al., I & I, 61(7):2741-2747, Jul. 1993.

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