Transformations of taxol

Details Transformations of taxol Transformations of taxol

1996-04-01

1998-07-28

Trinh, Ba K.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

549230, 549549, 549511, C07D31770

Patent

active

057864896

ABSTRACT:
A method for esterifying C13 deoxy taxoid intermediates employs three steps, i.e., oxygenation of the C13 deoxy taxoid intermediate to produce a C13 enone taxoid intermediate; reduction of the C13 enone to produce an alcohol; followed by esterification of the C13 alcohol. Key intermediates include C13 deoxy taxoids; C13 enone substituted taxoids; and C1-C2 cyclo carbonate esters of taxoids.

REFERENCES:
patent: 5440057 (1995-08-01), Nicolaou
Nicolaou et al, J. Chem. Soc., Chem. Commun., pp. 295-296, 1994.

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