Transformation of human B-lympocytes with Epstein Barr virus and

Details Transformation of human B-lympocytes with Epstein Barr virus and Transformation of human B-lympocytes with Epstein Barr virus and

1987-04-23

1991-03-05

Moskowitz, Margaret

Chemistry: molecular biology and microbiology

Spore forming or isolating process

530387, 530809, 530808, 530828, 435 7021, 435 696, 4351722, 4351723, 43524021, 4352402, 43524026, 4353201, 935 32, 935 34, 935 57, 935 71, 935 93, 935100, 935108, 935109, C07K 1528, C12N 522, C12N 524, C12N 1585

Patent

active

049977644

ABSTRACT:
Disclosed herein is a method for transforming human B-cells by infecting them with Epstein Barr virus and transfecting the Epstein Barr virus infected cells with an activated human c-myc gene. The transformed cells are useful for producing human monoclonal antibodies.

REFERENCES:
patent: 4701409 (1987-12-01), Croce
patent: 4740461 (1988-04-01), Kaufman
Lombardi et al., Cell, 49, 161-170, Apr. 24, 1987.
Kessler et al., Canc. Res., 47, 527-531, (Jan. 1987).
Dalla Favera et al., NYAS, vol. 511, "Normal and Neoplastic Blood Cells; From Genes to Therapy", Disclosed Jun. 10-13, 1986 (Rome, Italy) published 1987, New York.
Wennborg et al., Int. J. Cancer, 40, 202-206, (1987).
Polack et al., Embo. J., 6(10), 2959-2964, 1987.
Van Meel et al., J. Immunol. Meth., 80, 267-276, (1985).

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