Transferrin receptor specific antibody-neuropharmaceutical or di

Details Transferrin receptor specific antibody-neuropharmaceutical or di Transferrin receptor specific antibody-neuropharmaceutical or di

1992-03-06

1993-01-26

Nucker, Christine M.

Drug, bio-affecting and body treating compositions

Lymphokine

424 858, 424 941, 5303873, 5303911, 5303917, 5303919, 530399, 53038822, 514 21, A61K 3944, A61K 3736, C07K 1702, C07K 1528

Patent

active

051821079

ABSTRACT:
The present invention pertains to a method for delivering a neuropharmaceutical or diagnostic agent across the blood brain barrier to the brain of a host. The method comprises administering to the host a therapeutically effective amount of an antibody-neuropharmaceutical or diagnostic agent conjugate wherein the antibody is reactive with a transferrin receptor. Other aspects of this invention include a delivery system comprising an antibody reactive with a transferrin receptor linked to a neuropharmaceutical or diagnostic agent and methods for treating hosts afflicted with a disease associated with a neurological disorder.

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